Evidence map›Paper›PMID 40425486›Full record

ArticleGenes, brain, and behavior2025

Vitamin C Transport Deficiency Alters Striatal Dopamine Gene Expression and Metabolism in YAC128 Huntington Disease Mice.

Adriana A Tienda, Fiona E Harrison, Jordyn M Wilcox

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, brain, and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adriana A TiendaDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-7549-762X
Fiona E HarrisonDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jordyn M WilcoxDepartment of Psychology, University of Notre Dame, Notre Dame, Indiana, USA.

Funding

Manganese exposure and genetic diversity in risk mechanisms for neurodevelopmental disordersR01ES035518 · NIEHS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BOWMAN, AARON B, HARRISON, FIONA EDITH · 2024 to 2025
$3.6M
Manganese exposure susceptibility as a modifier of excitotoxicity in Alzheimer's DiseaseR01ES031401 · NIEHS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BOWMAN, AARON B, HARRISON, FIONA EDITH · 2020 to 2024
$2.7M
NIEHS NIH HHS R01 ES031401NIEHS NIH HHS R01ES031401NIEHS NIH HHS R01ES035518
6 · The paper itself

Abstract

Neurodegeneration in Huntington disease (HD) contributes to dopaminergic system dysfunction via the loss of striatal medium spiny neurons expressing dopamine receptors. Given the key role for ascorbic acid (vitamin C) in dopamine synthesis and neurotransmission, we investigated whether mild cellular ascorbate deficiency accelerates dopaminergic dysfunction in the development of HD pathology and behavioral deficits. YAC128 mice expressing mutant human huntingtin were crossed with SVCT2

Indexed as

Ascorbic Acid DeficiencyCorpus StriatumDopamineHuntington DiseaseSodium-Coupled Vitamin C TransportersAnimalsAscorbic AcidHumansHuntingtin ProteinMaleMiceSerotoninAscorbic AcidDopamineHuntingtin ProteinSerotoninSodium-Coupled Vitamin C Transportersascorbic aciddopamineHuntington's diseasemouse behaviorSVCT2

Identifiers

PMID40425486
PMCPMC12116213

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.