Evidence map›Paper›PMID 40425443›Full record

ReviewTrends in cancer2025

Harnessing technologies to unravel gastric cancer heterogeneity.

Yuefan Wang, Ramon U Jin, Joanne Xu, Ding Chiao Lin, Zhenyu Sun, Yuanwei Xu, Qing K Li, Hui Zhang

Abstract readReview
In one paragraph

Review in Trends in cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
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  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuefan WangDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. Electronic address: ywang298@jhu.edu.
Ramon U JinDivision of Oncology and Gastroenterology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Joanne XuCollege of Engineering, The Ohio State University, Columbus, OH 43210, USA.
Ding Chiao LinDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Zhenyu SunDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Yuanwei XuDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Qing K LiDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Hui ZhangDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Wade Brown · 2000 to 2026
$30.8M
Proteogenomic Characterization of Tumor Tissues and Preclinical Models with High PrecisionU24CA271079 · NCI · JOHNS HOPKINS UNIVERSITY · PI DANIEL Wanyui CHAN, Hui Zhang · 2022 to 2026
$6.6M
The Comprehensive Proteome Characterization Center at Johns Hopkins: High Precision Discovery and Confirmation of Genoproteomic TargetsU24CA210985 · NCI · JOHNS HOPKINS UNIVERSITY · PI CHAN, DANIEL WANYUI, ZHANG, HUI · 2016 to 2020
$5.3M
Biomarker Reference LaboratoryU2CCA271895 · NCI · JOHNS HOPKINS UNIVERSITY · PI DANIEL Wanyui CHAN · 2023 to 2026
$4.6M
Development of a panel of multiplex biomarkers for the early detection of pancreatic ductal adenocarcinoma and high-risk lesionsU01CA274514 · NCI · JOHNS HOPKINS UNIVERSITY · PI Randall Brand, DANIEL Wanyui CHAN · 2023 to 2026
$3.2M
The Role of SOX2 and CDX2 in Barrett's Esophagus DevelopmentK08DK139376 · NIDDK · WASHINGTON UNIVERSITY · PI RAMON JIN · 2024 to 2026
$489k
NCI NIH HHS U01 CA274514NCI NIH HHS U24 CA210985NCI NIH HHS U24 CA271079NCI NIH HHS U2C CA271895NIDDK NIH HHS K08 DK139376NIDDK NIH HHS P30 DK052574
6 · The paper itself

Abstract

Gastric cancer arises from complex carcinogenic factor interactions, with limited treatment options due to the lack of targetable driver gene mutations and significant tumor heterogeneity. Recent studies have provided promising novel approaches to improve our understanding of gastric cancer heterogeneity through integrated characterization, combining genomics with emerging technologies. Delineating the molecular changes and targeting specific molecular subtypes will enhance the efficacy of gastric cancer treatment and improve clinical outcomes. This review provides a comprehensive overview of current technologies used in gastric cancer research, highlighting key discoveries and treatment strategies driven by these innovations. Finally, we discuss the emerging technology-guided directions and potential breakthroughs that could enhance the understanding of gastric cancer tumor heterogeneity, ultimately improving clinical outcomes.

Indexed as

Biomarkers, TumorGenetic HeterogeneityStomach NeoplasmsGenomicsHumansMolecular Targeted TherapyMutationPrecision MedicineBiomarkers, Tumorgastric cancermulti-omics technologysingle-cell analysistumor heterogeneity

Identifiers

PMID40425443
PMCPMC12350073

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.