Evidence map›Paper›PMID 40425398›Full record

ReviewTrends in endocrinology and metabolism: TEM2025

Understanding metabolic resilience by unraveling temporal dynamics of cellular responses.

Paniz Jasbi, Alex E Mohr, Meghana Hosahalli Shivananda Murthy, Judith Klein-Seetharaman

Abstract readReview
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. NADBiochemistry and biophysics reports · 2026
    Article
  3. Obesity Disrupts CtBP2-Mediated Maintenance of Transcriptional Equilibrium in Hypothalamic Feeding Circuitry.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  4. Process Optimization ofFoods (Basel, Switzerland) · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. International journal of molecular sciences · 2026
    Article
  12. Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paniz JasbiSystems Precision Engineering and Advanced Research (SPEAR), Theriome Inc., Phoenix, AZ, USA.
Alex E MohrSystems Precision Engineering and Advanced Research (SPEAR), Theriome Inc., Phoenix, AZ, USA; College of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Meghana Hosahalli Shivananda MurthySchool of Molecular Sciences, Arizona State University, Phoenix, AZ, USA.
Judith Klein-SeetharamanSystems Precision Engineering and Advanced Research (SPEAR), Theriome Inc., Phoenix, AZ, USA; College of Health Solutions, Arizona State University, Phoenix, AZ, USA; School of Molecular Sciences, Arizona State University, Phoenix, AZ, USA. Electronic address: judith.klein-seetharaman@asu.edu.

Funding

Interdisciplinary Systems-based Training for Precision NutritionT32DK137525 · NIDDK · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Li Liu, Corrie Marie Whisner · 2023 to 2026
$1.4M
Intergenerational Community Driven Training in Alzheimer's Disease Research: An AI+X ApproachT32AG082658 · NIA · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI JUDITH KLEIN, Baoxin Li · 2024 to 2026
$1.0M
NIA NIH HHS T32 AG082658NIDDK NIH HHS T32 DK137525
6 · The paper itself

Abstract

Metabolic resilience is essential for organismal homeostasis under diverse external pressures, because responding and adapting to stressors requires energy and drives changes at every omic level. The goal of this paper is to synthesize recent advances in understanding the intricate interplay, especially between metabolic and transcriptomic responses, involved in addressing external perturbations. We highlight the importance of timing and sequence in immediate and long-term adjustments; furthermore, we underscore the evolutionary significance of metabolic resilience and its potential for developing innovative therapeutic interventions, making it a timely contribution to contemporary biological, biomedical, and environmental research fields.

Indexed as

Adaptation, PhysiologicalStress, PhysiologicalAnimalsHomeostasisHumansevolutionary biologymicrobiotamultiomicsrobustnessstress adaptationstress resistance

Identifiers

PMID40425398
PMCPMC12439121

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.