Evidence map›Paper›PMID 40424940›Full record

ReviewCurrent opinion in cell biology2025

Condensate-membrane interactions shape membranes, tune cytoskeletal assembly, and localize mRNAs.

Wilton T Snead

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Combinatorial decision-making driven by multicomponent surface condensates.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Liquid-liquid phase separation in neural development.Cellular and molecular life sciences : CMLS · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Wilton T SneadDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: wilton.snead@northwestern.edu.

Funding

Cellular surfaces as regulators of biomolecular condensate assemblyK99GM149757 · NIGMS · DUKE UNIVERSITY · PI SNEAD, WILTON THOMAS · 2023 to 2024
$208k
NIGMS NIH HHS K99 GM149757
6 · The paper itself

Abstract

Biomolecular condensates have emerged as essential subcellular compartments. Although condensates organize biochemistry without a delimiting membrane, condensates frequently interact with membrane surfaces in diverse cellular contexts. Condensates and membranes reciprocally modulate each other, inducing membrane shape changes, establishing domains of distinct lipid composition, and catalyzing reactions within condensates. Here I discuss recent advancements in our understanding of the condensate-membrane interface, with a focus on membrane shaping, lipid organization, cytoskeletal regulation, and mRNA transport. I conclude by suggesting research avenues that may uncover new functions for membrane-associated condensates, with emphasis on the understudied role of RNA in the condensate-membrane interface.

Indexed as

Biomolecular CondensatesCell MembraneCytoskeletonRNA, MessengerAnimalsHumansRNA, MessengerActinBiomolecular condensatesMembranesMembrane trafficOrganellesRNATranslation

Identifiers

PMID40424940
PMCPMC12321232

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.