Evidence map›Paper›PMID 40424807›Full record

ArticleJournal of hazardous materials2025

Enhancing ecological risk assessment of dioxins in aquatic environments: AHR diversity and species sensitivity differences in tiger puffer (Takifugu rubripes).

Zhenhong Xue, Wanglong Zhang, Anran Ren, Sibel I Karchner, Diana G Franks, Yanjiao Zong, Yongchao Ma, Jiayi Wang, Yiqin Xu, Jiaming Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hazardous materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhenhong XueCollege of Life Sciences, Qufu Normal University, Qufu, Shandong 273165, China.
Wanglong ZhangCollege of Life Sciences, Qufu Normal University, Qufu, Shandong 273165, China. Electronic address: zhangwanglong@qfnu.edu.cn.
Anran RenCollege of Life Sciences, Qufu Normal University, Qufu, Shandong 273165, China.
Sibel I KarchnerBiology Department, Woods Hole Oceanographic Institution (WHOI), Woods Hole, MA 02543, United States.
Diana G FranksBiology Department, Woods Hole Oceanographic Institution (WHOI), Woods Hole, MA 02543, United States.
Yanjiao ZongCollege of Life Sciences, Qufu Normal University, Qufu, Shandong 273165, China.
Yongchao MaDepartment of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Jiayi WangCollege of Life Sciences, Qufu Normal University, Qufu, Shandong 273165, China.
Yiqin XuCollege of Life Sciences, Qufu Normal University, Qufu, Shandong 273165, China.
Jiaming LiCollege of Life Sciences, Qufu Normal University, Qufu, Shandong 273165, China.
Ning DingCollege of Life Sciences, Qufu Normal University, Qufu, Shandong 273165, China.
Chunchen LiuCollege of Life Sciences, Qufu Normal University, Qufu, Shandong 273165, China. Electronic address: liuchunchen7@163.com.
Mark E HahnBiology Department, Woods Hole Oceanographic Institution (WHOI), Woods Hole, MA 02543, United States.
Bin ZhaoState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Funding

AHR Signaling in Mammalian and Non-Mammalian ModelsR01ES006272 · NIEHS · WOODS HOLE OCEANOGRAPHIC INSTITUTION · PI HAHN, MARK E · 1999 to 2014
$4.1M
Understanding the origins and mechanisms of aryl hydrocarbon receptor promiscuityR01ES035261 · NIEHS · WOODS HOLE OCEANOGRAPHIC INSTITUTION · PI Mark E Hahn · 2023 to 2026
$2.0M
NIEHS NIH HHS R01 ES006272NIEHS NIH HHS R01 ES035261
6 · The paper itself

Abstract

Dioxins and dioxin-like compounds (DLCs) exert toxicity through the aryl hydrocarbon receptor (AHR), but species variations in AHR lead to differing sensitivities. Investigating the variation in AHR homolog diversity, expression levels, predominant forms, and AHR sensitivity across species-particularly in fish sensitive to dioxins-is essential for enhancing ecological risk assessment. This study focuses on the tiger puffer (Takifugu rubripes), identifying five AHRs and two ARNTs, with truAHR2a showing the highest expression and the truAHR1 subfamily displaying lower levels. All truAHRs are functional and can be activated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), with truARNT1 cooperating more efficiently with truAHRs than truARNT2. We determined EC

Indexed as

DioxinsReceptors, Aryl HydrocarbonTakifuguWater Pollutants, ChemicalAnimalsMolecular Docking SimulationPolychlorinated DibenzodioxinsRisk AssessmentSpecies SpecificityDioxinsPolychlorinated DibenzodioxinsReceptors, Aryl HydrocarbonWater Pollutants, ChemicalAHRs sensitivityAryl hydrocarbon receptorDioxinTakifugu rubripesToxic potential

Identifiers

PMID40424807
PMCPMC12213170

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.