Evidence map›Paper›PMID 40424363›Full record

ArticleScience signaling2025

SMAD2 S-palmitoylation promotes its linker region phosphorylation and T

Mingming Zhang, Tao Yu, Yinong Liu, Xuan Lu, Wenzhe Chen, Lixing Zhou, Yuejie Xu, Min Yang, Andrew D Miller, Hening Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science signaling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mingming ZhangHoward Hughes Medical Institute, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Tao YuHoward Hughes Medical Institute, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-7896-4625
Yinong LiuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.ORCID 0009-0009-0405-5686
Xuan LuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Wenzhe ChenDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-0758-1237
Lixing ZhouCenter of Gerontology and Geriatrics/National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0009-0001-1146-7808
Yuejie XuDepartment of Gastroenterology, Drum Tower Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China.
Min YangDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Andrew D MillerSection of Anatomic Pathology, Department of Population Medicine and Diagnostic Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.ORCID 0000-0001-6350-5581
Hening LinHoward Hughes Medical Institute, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-0255-2701

Funding

Design and development of HDAC11-specific chemical inhibitors for disease treatmentsR01AI153110 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI LIN, HENING, MILLER, ROBERT H. · 2021 to 2025
$3.5M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI153110
6 · The paper itself

Abstract

The transcriptional regulators SMAD2 and SMAD3 share the same primary signaling pathway in response to the cytokine TGFβ. However, whereas SMAD2 stimulates the differentiation of naive CD4

Indexed as

Cell DifferentiationEncephalomyelitis, Autoimmune, ExperimentalLipoylationMultiple SclerosisSmad2 ProteinTh17 CellsAcyltransferasesAnimalsDisease Models, AnimalHumansMiceMice, Inbred C57BLPhosphorylationSignal TransductionSTAT3 Transcription FactorAcyltransferasesSmad2 ProteinSmad2 protein, mouseStat3 protein, mouseSTAT3 Transcription Factor

Identifiers

PMID40424363
PMCPMC12234153

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.