ArticlePloS one2025
Anxiety and depression among patients with migraine: A single-center cross-sectional study in Malaysia.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Associations Between Type D Personality, Psychological Symptoms, Pain Severity, and Migraine-Related Outcomes in Women with Migraine.Journal of clinical medicine · 2026Article
- Investigating the Patent Foramen Ovale-Migraine Link in Southern Saudi Arabia.Neurosciences (Riyadh, Saudi Arabia) · 2026Observational
- Cumulative adverse childhood experiences increase migraine risk in later life in China: evidence from CHARLS with mediation and Mendelian randomization.The journal of headache and pain · 2026Article
- Impact of migraine on quality of life and disability: a matched cross-sectional comparative study in a tertiary hospital in Malaysia.Frontiers in neurology · 2026Article
- Efficacy and exploratory treatment-response modeling of acupuncture for acute migraine based on DIA proteomics: a study protocol for a randomized controlled trial.Frontiers in medicine · 2026Article
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10 authors.
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Abstract
backgroundMigraine is a chronic neurological problem with a psychological comorbidity. However, anxiety and depression among patients with migraine have not been thoroughly investigated in Southeast Asia. Thus, we aimed to elucidate the prevalence of anxiety and depression in patients with migraine, as well as the associated factors.
methodsThis cross-sectional study was conducted between March 2022 and March 2024 at the National University of Malaysia. The participants' data were collected prior to completing two questionnaires, including the Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder-7 (GAD-7), which were used to evaluate depression and anxiety, respectively.
resultsA total of 246 participants who were diagnosed with migraine were recruited for this study. The mean age of the participants was 46.19 years (SD: ± 14.75). Additionally, 77.6% of the participants were female. Moreover, 27.7% of the participants had anxiety alone, 15.9% had depression alone, and 11.8% had both anxiety and depression. A younger age (p = 0.03), earlier age of migraine onset (r(246) -0.178, p < 0.01), background history of asthma (r(246) 0.161, p < 0.05), lower household income range (r(246) -0.179, p < 0.01), increased pain severity (r(246) 0.211, p < 0.01), frequency of attack (r(246) 0.139, p < 0.05), use of NSAIDs (r(246) 0.134, p < 0.05), use of pizotifen (r(246) 0.169, p < 0.01), use of propranolol (r(246) 0.286, p < 0.01), use of sodium valproate (r(246) 0.146, p < 0.05), use of topiramate (r(246) 0.178, p < 0.01), use of more than one medication (r(246) 0.240, p < 0.01), use of cold therapy (r(246) 0.223, p < 0.01) and use of acupuncture (r(246) 0.260, p < 0.01) were associated with anxiety and depression in migraine patients.
conclusionsAnxiety and depression are commonly observed in patients with migraine in Asia. Routine assessments for anxiety and depression should be performed to ensure holistic management of migraine.
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