ArticleProceedings of the National Academy of Sciences of the United States of America2025
Self-reproduction as an autonomous process of growth and reorganization in fully abiotic, artificial and synthetic cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Degradation, Osmosis and the Emergence of Basic Functionalities in Abiotic Synthetic Life-like Chemical Systems.Life (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
We investigate mechanisms for the observed nonlinear growth in the number of polymer vesicles generated during a photo-Reversible Addition-Fragmentation Chain Transfer-based polymerization-induced self-assembly (PISA) reaction. Our experimental results reveal the presence of a self-reproduction process during which chemically active polymer protocells are chemically and autonomously generated in a light-stimulated one-pot reaction that starts from a homogeneous blend of non-self-assembling molecules and which, as observed microscopically, form vesicular objects that grow and multiply (reproduce) during irradiation with green light (530 nm) as the reaction proceeds. By using a filtration-based protocol, our experiments demonstrate that the self-reproduction process occurs concomitantly with the PISA process and results in a nonlinear increase in the number of polymer vesicles during photopolymerization which can only be ascribed to their reproduction via polymeric spores ejected from previously existing first-generation vesicles. The second and subsequent generations' vesicles also self-reproduce and continue the process of population growth.
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Registered trials
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