Evidence map›Paper›PMID 40424131›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Formation of giant ER sheets by pentadecanoic acid causes lipotoxicity in fission yeast.

Yojiro Hoshikawa, Natsuho Shirota, Hiroshi Tsugawa, Satoshi Kimura, Akihisa Matsuyama, Yoko Yashiroda, Hideaki Kakeya, Makoto Arita, Reiko Iizumi, Minoru Yoshida and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Yojiro HoshikawaDepartment of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
Natsuho ShirotaFood Science Program, School of Applied Biological Science, Hiroshima University, Hiroshima 739-8528, Japan.
Hiroshi TsugawaMetabolome Informatics Research Team, RIKEN Center for Sustainable Resource Science, Kanagawa 230-0045, Japan.ORCID 0000-0002-2015-3958
Satoshi KimuraTechnology Advancement Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
Akihisa MatsuyamaDepartment of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
Yoko YashirodaMetabolome Informatics Research Team, RIKEN Center for Sustainable Resource Science, Kanagawa 230-0045, Japan.
Hideaki KakeyaDivision of Medicinal Frontier Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.ORCID 0000-0002-4293-7331
Makoto AritaLaboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan.ORCID 0000-0001-9902-0463
Reiko IizumiCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, CA 92093.
Minoru YoshidaDepartment of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.ORCID 0000-0002-4376-5674
Shinichi NishimuraDepartment of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.ORCID 0000-0002-5998-3780

Funding

Japan Agency for Medical Research and Development (AMED) JP22zf0127007MEXT | Japan Science and Technology Agency (JST) JPMJER2101MEXT | Japan Science and Technology Agency (JST) JPMJND2305MEXT | Japan Society for the Promotion of Science (JSPS) JP15H05897 JP15H05898 and JP20H00495MEXT | Japan Society for the Promotion of Science (JSPS) JP17H06401 JP23H04882 and JP24H00493MEXT | Japan Society for the Promotion of Science (JSPS) JP19H05640 JP23H05473MEXT | Japan Society for the Promotion of Science (JSPS) JP21H02128 JP19H05640 JP23H05473MEXT | Japan Society for the Promotion of Science (JSPS) JP21J21126MEXT | Japan Society for the Promotion of Science (JSPS) JP21K18216 and JP24K02011Ministry of Education, Culture, Sports, Science and Technology (MEXT) JP23H04880 and JP23H04882
6 · The paper itself

Abstract

Excess amounts of saturated fatty acids (FAs) are toxic to organisms, a condition termed lipotoxicity, which is often accompanied by pleiotropic cellular and tissue dysfunction. Here, we show that pentadecanoic acid (C15:0) exerts toxicity on the fission yeast

Indexed as

Endoplasmic ReticulumFatty AcidsSchizosaccharomycesCoenzyme A LigasesLipidomicsSchizosaccharomyces pombe ProteinsCoenzyme A LigasesFatty AcidsSchizosaccharomyces pombe Proteinsendoplasmic reticulumlipotoxicityyeast

Identifiers

PMID40424131
PMCPMC12146749

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.