Evidence map›Paper›PMID 40423907›Full record

ArticleMaternal and child health journal2025

Interventions Initiated Before and After Pregnancy for Women who Experience Severe Nausea and Vomiting of Pregnancy: A Scoping Review.

Zeinab El-Dirani, Kurdo Araz, Ola Bazzi, Noreen O'Leary, Grainne Kent, Melanie Nana, Catherine Williamson, Joan Devin, Eileen O'Brien, Angela C Flynn

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Maternal and child health journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zeinab El-DiraniSchool of Population Health, Royal College of Surgeons in Ireland, Beaux Lane House, Lower Mercer Street D02 DH60 Ireland, Dublin, Ireland.ORCID http://orcid.org/0000-0002-3610-3816
Kurdo ArazSchool of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Ola BazziAmerican University of Beirut, Beirut, Lebanon.
Noreen O'LearySchool of Population Health, Royal College of Surgeons in Ireland, Beaux Lane House, Lower Mercer Street D02 DH60 Ireland, Dublin, Ireland.
Grainne KentSchool of Population Health, Royal College of Surgeons in Ireland, Beaux Lane House, Lower Mercer Street D02 DH60 Ireland, Dublin, Ireland.
Melanie NanaDepartment of Women & Children's Health, School of Life Course & Population Sciences, King's College London, London, SE1 7EH, UK.
Catherine WilliamsonInstitute of Reproductive and Developmental Biology, Imperial College London, London, W12 0NN, UK.
Joan DevinIrish Medicines in Pregnancy Service, The Rotunda Hospital, Dublin 1, Ireland.
Eileen O'BrienSchool of Biological and Health Science, Technological University Dublin, Dublin, Ireland.
Angela C FlynnSchool of Population Health, Royal College of Surgeons in Ireland, Beaux Lane House, Lower Mercer Street D02 DH60 Ireland, Dublin, Ireland. angelaflynn@rcsi.ie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNausea and vomiting of pregnancy (NVP) affects up to 90% of women, while hyperemesis gravidarum (HG), a severe form of NVP, impacts quality of life, and ability to eat and drink normally, with reported recurrence rates up to 89% in subsequent pregnancies. Severe NVP has a profound impact on maternal physical and mental health, impairing daily functioning and quality of life, and is associated with anxiety and depression.

aimsTo conduct a scoping review to identify and characterise interventions initiated before and after pregnancy that aim to mitigate the impact and consequences of severe NVP on maternal health.

methodsA comprehensive search was conducted across seven electronic databases and included grey literature without restrictions on language or date. Eligible studies were identified according to a prespecified criteria. All references were screened independently by two reviewers.

findingsThree studies were included; two utilised pre-emptive counselling and antiemetic treatment beginning before pregnancy or in early pregnancy/upon recognition of pregnancy, while one focused on post-pregnancy writing therapy. Both pre-emptive interventions reported a reduction in NVP symptom severity and a lower recurrence rate of HG, while writing therapy was beneficial in aiding recovery from severe NVP and allowed women an opportunity to externalise and process the experience. DISCUSSION: This study revealed a paucity of interventions initiated before and after pregnancy for women with severe NVP. The included studies showed some benefits of pre-emptive treatment and writing therapy.

conclusionTailored pre-pregnancy and postpartum interventions for women with previous severe NVP are urgently needed to address the physical and mental health burden of the condition.

Indexed as

Hyperemesis GravidarumNauseaPregnancy ComplicationsVomitingAntiemeticsFemaleHumansPregnancyQuality of LifeAntiemeticsHyperemesis gravidarumNausea and vomiting of pregnancyPostpartumPreconception

Identifiers

PMID40423907
PMCPMC12206181

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.