ArticleProbiotics and antimicrobial proteins2025
Synbiotic Supplementation Mitigates Antibiotic-Associated Diarrhea by Enhancing Gut Microbiota Composition and Intestinal Barrier Function in a Canine Model.
Article in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Host-derived Pediococcus Acidilactici GLP06 Mitigates antibiotic-associated Diarrhoea in Dogs.Probiotics and antimicrobial proteins · 2026Article
- Integrated Multi-Omics Analysis Explores the Protective Effects and Potential Mechanisms ofBiomolecules · 2026Article
- Herbal and Natural Product Interventions in Animal Models of Antibiotic-Associated Diarrhea and Their Effects on Gut Microbiota: a protocol for systematic review.Journal of pharmacopuncture · 2026Review
- Herbal and Natural Products for Antibiotic-Associated Diarrhea: A Systematic Review of Animal Studies Focusing on Molecular Microbiome and Barrier Outcomes.Pharmaceuticals (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic-associated diarrhea (AAD) remains a significant clinical challenge, with current treatments often inadequate for fully restoring gut health. This study aimed to evaluate the effectiveness of synbiotics, including chitosan oligosaccharides, Bifidobacterium, Clostridium butyricum, and Lactiplantibacillus plantarum, in mitigating AAD in a canine model. Sixteen Beagle dogs were randomly assigned to an AAD model group or a synbiotic treatment group. Synbiotic supplementation significantly reduced diarrhea severity, improved intestinal morphology, and enhanced gut microbiota diversity. Furthermore, synbiotics upregulated the expression of tight junction proteins (ZO-1, occludin, claudin-1), thereby reducing mucosal permeability. A significant decrease in proinflammatory cytokines (IL-1β, TNF-α) further underscored the anti-inflammatory effects of the treatment. These findings suggest that synbiotics may offer a promising approach to restoring gut barrier integrity and modulating immune responses in cases of AAD. Further research is warranted to investigate the long-term impacts and underlying mechanisms of synbiotics in gut health restoration.
Indexed as
Identifiers
40423877What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.