Evidence map›Paper›PMID 40423811›Full record

ArticleAnnals of hematology2025

The expression patterns and prognostic significance of PD-1 and TIM-3 on T cells and the differentiated subsets in acute myeloid leukemia.

Kai Sun, Zong-Yan Shi, Ya-Zhe Wang, Dai-Hong Xie, Yan-Rong Liu, Qian Jiang, Hao Jiang, Xiao-Jun Huang, Ya-Zhen Qin

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PubMed Full text at PMC Publisher
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Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kai SunPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China.
Zong-Yan ShiPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China.
Ya-Zhe WangPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China.
Dai-Hong XiePeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China.
Yan-Rong LiuPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China.
Qian JiangPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China.
Hao JiangPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China.
Xiao-Jun HuangPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China.
Ya-Zhen QinPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, 100044, PR China. qin2000@aliyun.com.ORCID http://orcid.org/0000-0002-1548-0946

Funding

National Natural Science Foundation of China 82070153
6 · The paper itself

Abstract

Researches on the immune checkpoint molecule and its clinical application in acute myeloid leukemia (AML) fall behind solid tumors. The expression patterns and prognostic significance of immune checkpoint molecules across T cells and T-cell differentiated subsets in AML require further elucidation. In the present study, bone marrow (BM) samples from 165 newly diagnosed AML patients and 12 healthy donors (HDs) were tested PD-1 and TIM-3 expression on CD4

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesGene Expression Regulation, LeukemicHepatitis A Virus Cellular Receptor 2Leukemia, Myeloid, AcuteNeoplasm ProteinsProgrammed Cell Death 1 ReceptorAdolescentAdultAgedAged, 80 and overCell DifferentiationFemaleHumansMaleMiddle AgedHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2Neoplasm ProteinsPDCD1 protein, humanProgrammed Cell Death 1 ReceptorAcute myeloid leukemiaAt diagnosisPD-1Prognostic significanceT cellTIM-3

Identifiers

PMID40423811
PMCPMC12283477

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.