Evidence map›Paper›PMID 40423780›Full record

ArticleCurrent topics in microbiology and immunology2025

A Critical Role for Epstein-Barr Virus in Primary Effusion Lymphoma.

Beniah Brumbaugh, Bill Sugden

Abstract read
In one paragraph

Article in Current topics in microbiology and immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Beniah BrumbaughMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA.ORCID https://orcid.org/0000-0002-9786-9786
Bill SugdenMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI, USA. sugden@oncology.wisc.edu.ORCID https://orcid.org/0000-0002-8724-4504

Funding

Visualizing EBV and HCMV DNA Dynamics During InfectionP01CA022443 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Paul F. Lambert · 1985 to 2026
$53.1M
NCI NIH HHS P01 CA022443
6 · The paper itself

Abstract

Some human cancers are caused by coinfections with two viruses. Here we focus on primary effusion lymphomas (PEL), which arise from coinfection of B cells with Kaposi's Sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) and often are accompanied by systemic infections with human immunodeficiency virus (HIV). Both KSHV and EBV contribute to this oncogenesis of a rare B cell subset and HIV, by limiting the host immune response to coinfected cells, can too. Some of the mechanisms underlying the lymphomagenesis mediated by two tumor viruses are clear; some remain to be elucidated.

Indexed as

B cell lymphomaEBVGamma herpesvirusHIVHIV-associated lymphomaKSHVOncogenic virusPrimary effusion lymphomaViral coinfection

Identifiers

PMID40423780
PMCPMC12851538

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.