Observational studyEuropean geriatric medicine2025
Frailty is associated with a history of falls among mobility-limited older adults-cross-sectional multivariate analysis from the BIOFRAIL study.
Observational study in European geriatric medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05795556 (Biomarkers of Sarcopenia and Frailty in Geriatric Patients), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Biomarkers of Sarcopenia and Frailty in Geriatric Patients
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Timed Up-and-Go as a predictor of fracture risk: a systematic review and meta-analysis in a population of over 1.6 million people.Frontiers in public health · 2026Pooled it
- Associations between nutritional risk indices and fall history in older adults: a retrospective cross-sectional study.BMC geriatrics · 2026Article
- Assessment of physical function of hospitalized older patients in routine clinical practice predicts 1-year mortality; A cohort study of 5,062 medical and surgical patients.European geriatric medicine · 2026Article
- Dysmobility Syndrome, Osteosarcopenia, and Frailty: An ICF-Based Framework to Differentiate Function, Tissue, and Reserve.Journal of frailty, sarcopenia and falls · 2026Article
- Remote Monitoring of Instrumental Activities of Daily Living Reveals Intrinsic Capacity in Older Adults.Gerontology · 2026Article
- Fear of falling among housebound older adults: a quantitative study.BMC geriatrics · 2025Article
- Gaming Against Frailty: Effects of Virtual Reality-Based Training on Postural Control, Mobility, and Fear of Falling Among Frail Older Adults.Journal of clinical medicine · 2025Article
- Oral Health Conditions and Physical Performance in Two Different Professional Team Sports in Germany: A Cross-Sectional Study.Sports (Basel, Switzerland) · 2025Article
- Impact of frailty on rehabilitation exercise adherence in patients with ischemic stroke.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo identify differences in characteristics between mobility-limited older adults with a history of falls and those at risk of falling but who have not yet fallen.
findingsFrailty and muscle strength were characteristics distinguishing between older adults with a history of falls and those absent of falls despite an increased risk of falling. MESSAGE: Frailty should be incorporated alongside handgrip strength (HGS) and sit-to-stand (STS) tests into routine evaluations of mobility-limited older adults referred for fall assessment. PURPOSE: We aimed to identify differences in characteristics between mobility-limited older adults with a history of falls and those at risk of falling, and to identify the parameter with the strongest predictive value on the risk of falling.
methodsData included anthropometry, HGS, 30-s and 5-reps STS tests, maximal isometric knee extensor strength, gait speed (6 m), postural balance (tandem test), and muscle mass (BIA). Frailty was assessed using the Clinical Frailty Scale (CFS) and sarcopenia was evaluated according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) guidelines. Outcomes of falls (past year), and depression (Geriatric Depression Scale 15) were self-reported.
resultsTotally, 505 mobility-limited older adults (mean age 79.7 ± 6.3 years, 64.8% females) were included. Of these, 400 (79.2%) had experienced one or more falls within the past year (fallers), while 105 (20.8%) had not experienced a fall (at risk). Patients with experienced falls were more likely to feel depressed, had reduced handgrip strength, and reduced performance in both STS tests compared to those who had not fallen. Frailty was the strongest individual parameter associated with a history of prior falls, even after adjusting for covariates such as depression and 30-s STS (aOR 3.80; 95% CI 1.70-8.50).
conclusionsPresent study identified frailty as a key factor independently associated with a history of falls in this population. Additionally, handgrip strength and STS performance were key characteristics distinguishing between older adults with a history of falls within the past 12 months and those at risk of falling.
trial registrationNCT05795556.
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