Evidence map›Paper›PMID 40423698›Full record

ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2025

Exploring perivascular epithelioid cell tumors (PEComas) in the CNS: insights from two case reports and a comprehensive literature review.

Rik Demaerel, Brecht Decraene, Pegah Masrori, Lukas Marcelis, Raf Sciot, Philippe Demaerel, Frank Van Calenbergh

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rik Demaerel *Department of Neurosurgery, University Hospitals Leuven, Louvain, Belgium.
Brecht Decraene *Department of Neurosurgery, University Hospitals Leuven, Louvain, Belgium. brecht.decraene@uzleuven.be.ORCID 0000-0002-2523-452X
Pegah MasroriDepartment of Neurology, University Hospitals Leuven, Louvain, Belgium.ORCID 0000-0001-8247-1866
Lukas MarcelisDepartment of Pathology, University Hospitals Leuven, Louvain, Belgium.
Raf SciotDepartment of Pathology, University Hospitals Leuven, Louvain, Belgium.
Philippe DemaerelDepartment of Radiology, University Hospitals Leuven, Louvain, Belgium.
Frank Van CalenberghDepartment of Neurosurgery, University Hospitals Leuven, Louvain, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perivascular epithelioid cell tumors (PEComas) represent a rare and intriguing subset of neoplasms within the central nervous system (CNS). This report describes two unique cases that highlight distinct origins and clinical behaviors, offering valuable contributions to the limited body of knowledge regarding CNS PEComas. Despite their rarity, PEComas should be considered in the differential diagnosis of mesenchymal tumors that display an atypical combination of clinical, radiological, and histomolecular features, especially when melanocytic and/or myoid markers are present. Treatment with mTOR inhibitors can potentially stabilize the disease in a significant number of more aggressive PEComas, even those located in the CNS.

Indexed as

Brain NeoplasmsCentral Nervous System NeoplasmsPerivascular Epithelioid Cell NeoplasmsHumansMelanocyticMesenchymal tumorsMTOR inhibitorsMyoidPecoma

Identifiers

PMID40423698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.