Evidence map›Paper›PMID 40423694›Full record

ArticleJournal of neurology2025

Eye movement abnormalities in normal pressure hydrocephalus: a video-oculographic study.

Alessio Facchin, Jolanda Buonocore, Giulia Sgrò, Alessia Cristofaro, Marianna Crasà, Chiara Camastra, Maria Grazia Vaccaro, Aldo Quattrone, Andrea Quattrone

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Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessio Facchin *Neuroscience Research Center, Magna Graecia University, Viale Europa, 88100, Catanzaro, Italy.ORCID http://orcid.org/0000-0002-0604-5029
Jolanda Buonocore *Department of Medical and Surgical Sciences, Institute of Neurology, Magna Graecia University, Catanzaro, Italy.ORCID http://orcid.org/0000-0002-3813-283X
Giulia SgròNeuroscience Research Center, Magna Graecia University, Viale Europa, 88100, Catanzaro, Italy.ORCID http://orcid.org/0009-0003-6181-3881
Alessia CristofaroNeuroscience Research Center, Magna Graecia University, Viale Europa, 88100, Catanzaro, Italy.ORCID http://orcid.org/0009-0005-5153-5595
Marianna CrasàNeuroscience Research Center, Magna Graecia University, Viale Europa, 88100, Catanzaro, Italy.ORCID http://orcid.org/0000-0001-5676-6249
Chiara CamastraNeuroscience Research Center, Magna Graecia University, Viale Europa, 88100, Catanzaro, Italy.ORCID http://orcid.org/0009-0007-0172-5125
Maria Grazia VaccaroNeuroscience Research Center, Magna Graecia University, Viale Europa, 88100, Catanzaro, Italy.ORCID http://orcid.org/0000-0001-8666-0461
Aldo QuattroneNeuroscience Research Center, Magna Graecia University, Viale Europa, 88100, Catanzaro, Italy.ORCID http://orcid.org/0000-0003-2001-957X
Andrea QuattroneNeuroscience Research Center, Magna Graecia University, Viale Europa, 88100, Catanzaro, Italy. an.quattrone@unicz.it.ORCID http://orcid.org/0000-0003-2071-2083

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEye movement dysfunction has been widely observed in several neurodegenerative diseases. Normal pressure hydrocephalus (NPH) is a treatable condition showing marked clinical and radiological overlap with neurodegenerative parkinsonism and dementia syndromes, often posing diagnostic challenges. The current study employed video-oculography (VOG) aiming to comprehensively explore possible ocular dysfunction in NPH patients.

methodsForty-two consecutive NPH patients and seventy-six healthy controls (HC) were enrolled in the study. Participants underwent a video-oculographic assessment including reflexive saccades and fixation tasks. Amplitude, peak velocity and latency of upward, downward, and vertical saccades were calculated, together with square wave jerks (SWJ) number and amplitude during fixation. Correlations between VOG data and clinico-radiological features were investigated.

resultsNPH patients showed a significant (33.8%) increase in saccadic latency compared to HC, with no differences in saccadic amplitude and peak velocity. The number and amplitude of SWJ were also similar between NPH and HC groups. Saccadic latency was specifically associated with cognitive deficits, especially phonemic fluency and executive functions, in the NPH group.

conclusionThis study characterized ocular dysfunction in NPH patients, demonstrating an increase of saccadic latency in comparison with HC, strongly associated with cognitive impairment. These results identified saccadic latency as a rapid and quantitative VOG biomarker of cognitive deficits in NPH, holding potential for repeated assessment of cognitive status over time. On the other hand, saccadic amplitude and velocity were not affected in NPH, thus suggesting their possible role in the differential diagnosis between NPH and neurodegenerative parkinsonian syndromes.

Indexed as

Hydrocephalus, Normal PressureOcular Motility DisordersAgedAged, 80 and overCognitive DysfunctionEye Movement MeasurementsFemaleHumansMaleMiddle AgedSaccadesVideo RecordingCognitive impairmentEye movementNormal pressure hydrocephalusSaccadic latencyVideo-oculography

Identifiers

PMID40423694

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.