Evidence map›Paper›PMID 40423692›Full record

ArticleeLife2025

A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers.

Robert G Stewart, Matthew James Marquis, Sooyeon Jo, Brandon J Harris, Aman S Aberra, Verity Cook, Zachary Whiddon, Vladimir Yarov-Yarovoy, Michael Ferns, Jon T Sack

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Electrically Silent Kv5.1 Subunit Forms Heteromeric Kv2 Channels in Cortical Neurons and Confers Distinct Functional Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Robert G StewartDepartment of Physiology and Membrane Biology, University of California Davis, Davis, United States.ORCID https://orcid.org/0009-0003-5407-0346
Matthew James MarquisDepartment of Physiology and Membrane Biology, University of California Davis, Davis, United States.ORCID https://orcid.org/0000-0002-5556-9072
Sooyeon JoDepartment of Neurobiology, Harvard Medical School, Boston, United States.
Brandon J HarrisDepartment of Physiology and Membrane Biology, University of California Davis, Davis, United States.ORCID https://orcid.org/0000-0003-3894-0180
Aman S AberraNeurobiology Course, Marine Biological Laboratory, Woods Hole, United States.ORCID https://orcid.org/0000-0002-4805-541X
Verity CookNeurobiology Course, Marine Biological Laboratory, Woods Hole, United States.
Zachary WhiddonNeurobiology Course, Marine Biological Laboratory, Woods Hole, United States.
Vladimir Yarov-YarovoyDepartment of Physiology and Membrane Biology, University of California Davis, Davis, United States.ORCID https://orcid.org/0000-0002-2325-4834
Michael FernsDepartment of Physiology and Membrane Biology, University of California Davis, Davis, United States.ORCID https://orcid.org/0000-0002-1545-3024
Jon T SackDepartment of Physiology and Membrane Biology, University of California Davis, Davis, United States.ORCID https://orcid.org/0000-0002-6975-982X

Funding

Ion Channel Pharmacology for Pain and EpilepsyR35NS127216 · NINDS · HARVARD MEDICAL SCHOOL · PI BRUCE P BEAN · 2022 to 2026
$3.6M
Neurobiology Summer CourseR25NS063307 · NINDS · MARINE BIOLOGICAL LABORATORY · PI Ricardo C Araneda, Michael Blake Hoppa · 2008 to 2026
$3.5M
Generation of tools for visualizing understudied KvS potassium channel proteinsR03TR004200 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FERNS, MICHAEL J, SACK, JON THOMAS · 2022 to 2022
$159k
NCATS NIH HHS R03 TR004200NIH HHS R03-TR004200NIH HHS R25-NS063307NIH HHS R35-NS127216NINDS NIH HHS R25 NS063307NINDS NIH HHS R35 NS127216University of California Davis R03-TR004200
6 · The paper itself

Abstract

KvS proteins are voltage-gated potassium channel subunits that form functional channels when assembled into heteromers with Kv2.1 (

Indexed as

NeuronsPotassium Channel BlockersShab Potassium ChannelsAnimalsHumansMiceSpider VenomsPotassium Channel BlockersShab Potassium ChannelsSpider Venomschinese hamster ovary (CHO) cellsguangxitoxin-1E (GxTX)humanhuman neuronsmolecular biophysicsmousemouse neuronsneuroscienceRY785structural biologyvoltage-gated potassium channel

Identifiers

PMID40423692
PMCPMC12113274

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.