Evidence map›Paper›PMID 40423644›Full record

ArticleJACC. Basic to translational science2025

Preclinical Evaluation of a Novel Cryo Renal Denervation System.

Florian Krackhardt, Konstantinos Tsioufis, Lucas Lauder, Natascha Drude, Jo Adaway, Brian Keevil, Holger Klemm, Wolfram Haider, Alicia Beele, Léa Wild and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Florian KrackhardtDeutsches Herzzentrum der Charité Universitätsmedizin Berlin, Klinik mit Schwerpunkt Kardiologie, Angiologie und Intensivmedizin, Berlin, Germany. Electronic address: florian.krackhardt@gmx.de.
Konstantinos TsioufisFirst Cardiology Department, School of Medicine, "Hippokration" General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Lucas LauderDepartment of Cardiology, University Heart Center, University Hospital Basel, Basel, Switzerland; Cardiovascular Research Institute Basel (CRIB), University Heart Center, University Hospital Basel, Basel, Switzerland.
Natascha DrudeBerlin Institute of Health at Charité Universitätsmedizin Berlin, Germany.
Jo AdawayUniversity Hospital of South Manchester NHS Foundation, Manchester, United Kingdom.
Brian KeevilUniversity Hospital of South Manchester NHS Foundation, Manchester, United Kingdom.
Holger KlemmCryovasc GmbH, Berlin, Germany.
Wolfram HaiderInstitut für Tierpathologie Berlin, Berlin, Germany.
Alicia BeeleDeutsches Herzzentrum München, München, Germany.
Léa WildDeutsches Herzzentrum München, München, Germany.
Michael JonerDeutsches Herzzentrum München, München, Germany.
Felix MahfoudDepartment of Cardiology, University Heart Center, University Hospital Basel, Basel, Switzerland; Cardiovascular Research Institute Basel (CRIB), University Heart Center, University Hospital Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to demonstrate the safety and efficacy of a novel cryo renal denervation system (Cryo-RDN) in a porcine model. Procedural and mid-term safety of the Cryo-RDN was demonstrated. Efficacy of the cryoablation was evidenced by histological findings in the renal arteries and reduced renal tissue norepinephrine concentrations on the treated sides. Despite some morphological nerve repair observed between 7 and 28 days, the greater renal norepinephrine suppression in the 28-day animals suggests irreversibly ablated sympathetic nerves.

Indexed as

ablationcryoenergyhypertensionporcine modelrenal denervationsympathetic nerves

Identifiers

PMID40423644
PMCPMC12230487

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.