ArticleTranslational vision science & technology2025
The Efficacy and Safety of Oxygen-Enriched Rose Bengal and Green Light Corneal Crosslinking.
Article in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To evaluate the efficacy and safety of Rose Bengal (RB) and green light crosslinking (RGX) with supplemental oxygen. Methods: Rabbits were divided into three groups. Rabbits in the control group were de-epithelialized and served as controls. Rabbits in the RGX-nO2 group were de-epithelialized, stained with 0.1% RB for 20 minutes, and then exposed to green light at 0.25 W/cm2 for 10 minutes in an ambient atmospheric oxygen environment. Rabbits in the RGX-hO2 group received the same treatment as group 2, but supplemental oxygen was given to the ocular surface during irradiation. Central corneal thickness was measured at various points during RGX. After RGX, corneal microstructure, corneal biomechanics, and resistance to enzyme lysis were evaluated. Results: RGX-hO2 and RGX-nO2 significantly increased the corneal tensile strength by factors of 1.76 and 1.46, respectively. The times for complete corneal digestion within the RGX-hO2, RGX-nO2, and control groups were 23.2 ± 1.1 hours, 18.0 ± 2.0 hours, and 8.4± 0.9 hours. The average collagen fibril diameters (43.58 ± 0.93 nm, 40.46 ± 1.11 nm, and 35.25 ± 0.75 nm, respectively) and surface-to-surface spacing (11.67 ± 1.91 nm, 15.51 ± 1.66 nm, and 24.93 ± 1.95 nm, respectively) also differed statistically among the three groups. No evidence of endothelial or stromal cell damage was detected by endothelial staining or TUNEL assay. Conclusions: Increasing the concentration of oxygen during the irradiation process enhances RGX efficacy without causing obvious damage to a rabbit's endothelium or stromal cells. Translational Relevance: The study can potentially help with improvement of the existing clinical crosslinking protocol.
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