Evidence map›Paper›PMID 40423614›Full record

ArticleTranslational vision science & technology2025

Presbyopia Progression From the Age of 40 to 79 Years in Glaucoma Patients Treated With Prostaglandin F Receptor Agonists.

Masahiko Ayaki, Akiko Hanyuda, Kazuno Negishi

Abstract read
In one paragraph

Article in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Masahiko AyakiDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Akiko HanyudaDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Kazuno NegishiDepartment of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The aim of this study was to compare the near add power of glaucoma patients and controls between the ages of 40 and 79 years. Methods: This was a cross-sectional study of 2724 bilateral phakic participants aged between 40 and 79 years, which included 1615 controls and 1109 patients with primary open-angle glaucoma who were using prostaglandin F (FP) receptor agonists. Participants were classified into eight age groups: 40-44, 45-49, 50-54, 55-59, 60-64, 65-69, 70-74, and 75-79 years of age. We compared the near add power and other ocular parameters between glaucoma patients and controls by age group. Results: There was a significant difference between glaucoma patients and controls and in spherical equivalent, intraocular pressure, cup/disc ratio, ganglion cell complex thickness, peripapillary retinal nerve fiber layer thickness, and use of dry eye eyedrops across all or many of the age groups studied. The near add power of glaucoma patients was comparable to controls of the immediately older age group until 65-69 years, indicating that the advancement of near add power of glaucoma patients was approximately five years earlier than in controls until that age range. Conclusions: There was an earlier progression of presbyopia determined by near add power in glaucoma patients treated with FP receptor agonists compared with controls. Translational Relevance: Between ages 40 and 79 years, glaucoma patients treated with prostaglandin F receptor agonists had higher near add power than controls. This knowledge could contribute to informing better management of glaucoma patients with presbyopia.

Indexed as

Glaucoma, Open-AnglePresbyopiaReceptors, ProstaglandinAdultAgedAntihypertensive AgentsCross-Sectional StudiesDisease ProgressionFemaleGlaucomaHumansIntraocular PressureMaleMiddle AgedAntihypertensive Agentsprostaglandin F2alpha receptorReceptors, Prostaglandin

Identifiers

PMID40423614
PMCPMC12124147

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.