Evidence map›Paper›PMID 40423554›Full record

ArticleUrology practice2025

Clinical Outcomes of Holmium Laser Enucleation of the Prostate in Patients With Diminished Bladder Contractility.

Krista N Brackman, Madison T Taychert, Emily C Serrell, Daniel Gralnek, Christopher Manakas, Margaret Knoedler, Ali Antar, Glenn O Allen, Matthew D Grimes

Abstract read
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In one paragraph

Article in Urology practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Krista N BrackmanDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Madison T TaychertDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Emily C SerrellDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Daniel GralnekDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Christopher ManakasDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Margaret KnoedlerDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Ali AntarDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Glenn O AllenDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Matthew D GrimesDepartment of Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.ORCID 0000-0002-4409-9263

Funding

Wisconsin Multidisciplinary K12 Urologic Research Career Development ProgramK12DK100022 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI CHAD M. VEZINA · 2013 to 2026
$8.6M
NIDDK NIH HHS K12 DK100022
6 · The paper itself

Abstract

introductionBladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH) is common in aging men and can be treated with holmium laser enucleation of the prostate (HoLEP). However, diminished bladder contractility (DC) is also highly prevalent (9%-48%) and can be clinically indistinguishable from BOO without urodynamics (UDS). While HoLEP effectively treats BPH/BOO, clinical outcomes data for patients with DC are limited and mixed. We aim to compare the prevalence and risk factors of catheter dependence among patients with and without DC after HoLEP.

methodsA retrospective cohort study was conducted on 179 patients with preoperative UDS who underwent HoLEP between June 2018 and December 2023. Diminished contractility was defined as Bladder Contractility Index (BCI) < 100. Statistical analyses included univariate and multivariate logistic regression.

resultsAmong 179 patients, 103 (57.5%) had DC (BCI < 100). After HoLEP, all patients with normal contractility (NC) were voiding while 7.8% of patients with DC were catheter dependent (

conclusionsHoLEP rendered 95.5% (171/179) of patients catheter free. However, patients with DC were more likely to require catheterization postoperatively and reported worse urinary symptoms compared with patients with NC. Our results support obtaining UDS when there is clinical concern for DC because this may guide shared decision-making before pursuing HoLEP.

Indexed as

Lasers, Solid-StateProstatectomyProstatic HyperplasiaUrinary BladderUrinary Bladder Neck ObstructionAgedAged, 80 and overHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeUrodynamicsbladder contractility indexbladder hypocontractilitydetrusor underactivityHoLEPurodynamics

Identifiers

PMID40423554
PMCPMC12382733

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.