Evidence map›Paper›PMID 40423434›Full record

ArticleToxics2025

Ellagic Acid Alleviates Imidacloprid-Induced Thyroid Dysfunction via

Amina A Farag, Mahmoud Mostafa, Reham M Abdelfatah, Alshimaa Ezzat ELdahshan, Samar Fawzy Gad, Shimaa K Mohamed, Mona K Alawam, Aya Aly Elzeer, Nesma S Ismail, Sally Elsharkawey and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Amina A FaragDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Benha University, Benha 13518, Egypt.ORCID 0000-0003-3014-9909
Mahmoud MostafaDepartment of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.ORCID 0000-0001-6425-9247
Reham M AbdelfatahDepartment of Pesticides, Faculty of Agriculture, Mansoura University, Mansoura 35516, Egypt.ORCID 0000-0002-6542-749X
Alshimaa Ezzat ELdahshanDepartment of Histology, Faculty of Medicine, Benha University, Benha 13518, Egypt.
Samar Fawzy GadDepartment of Anatomy, Faculty of Medicine, Benha University, Benha 13518, Egypt.
Shimaa K MohamedDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt.
Mona K AlawamDepartment of Physiology, Faculty of Medicine, Benha University, Benha 13518, Egypt.
Aya Aly ElzeerDepartment of Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.
Nesma S IsmailDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Benha University, Benha 13518, Egypt.
Sally ElsharkaweyDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Benha University, Benha 13518, Egypt.
Haneen A Al-MazrouaDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-5838-3468
Hatun A AlomarDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-7495-0592
Wedad S SarawiDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-6376-9464
Heba S YoussefDepartment of Physiology, Faculty of Medicine, Benha University, Benha 13518, Egypt.ORCID 0000-0002-8267-1718

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imidacloprid (IMI) is a widely used insecticide known for its high selectivity toward insects. Ellagic acid (EA) is a plant-derived polyphenolic compound recognized for its therapeutic potential and favorable safety profile in the treatment of various diseases. This study aimed to evaluate the therapeutic effects of EA, formulated as novasomes (NOV), against IMI-induced thyroid dysfunction and to investigate the underlying mechanisms. Rats were divided into four equal groups: control, EA-NOV, IMI, and IMI + EA-NOV. Thyroid function was assessed by measuring free triiodothyronine (T3), free thyroxine (T4), and thyroid-stimulating hormone (TSH) levels. Thyroid tissues were examined to evaluate histopathological alterations, as well as to assess the oxidative/antioxidant pathway (Nrf2, SOD, TAC, MDA), inflammatory pathway (IL-1β, TNF-α, NF-κB), apoptotic pathway (

Indexed as

autophagyellagic acidimidaclopridnetwork pharmacologynovasomesthyroid dysfunction

Identifiers

PMID40423434
PMCPMC12115864

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.