Evidence map›Paper›PMID 40423432›Full record

ArticleToxics2025

Long-Term Exposure to Microplastics Promotes Early-Stage Hepatocarcinogenesis Induced by Diethylnitrosamine in Rats by Modulation of Their Gut Microbiota.

Huina Guo, Jianan Wang, Shaowen Huang, Suren Rao Sooranna, Fangyi Shu, Genliang Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huina GuoSchool of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise 533000, China.ORCID 0009-0002-6446-603X
Jianan WangSchool of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise 533000, China.
Shaowen HuangDepartment of Laboratory Medicine, Baise People's Hospital, Baise 533000, China.
Suren Rao SoorannaDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London SW10 9NH, UK.ORCID 0000-0001-8562-9980
Fangyi ShuSchool of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise 533000, China.
Genliang LiSchool of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise 533000, China.

Funding

Baise City Scientific Research and Technology Development Plan 20233649The Middle-aged Teachers Basic Research Ability Improvement Project 2022KY0544
6 · The paper itself

Abstract

Hepatocarcinogenesis is linked to environmental factors, with microplastics (MPs) emerging as a global environmental concern that may contribute to liver injury. However, the impact of MPs on the early stages of hepatocarcinogenesis has been largely ignored. Here we investigated the impact of long-term MP exposure on the formation of preneoplastic lesions during hepatocarcinogenesis induced by diethylnitrosamine (DEN) in rats. Rats were injected with DEN to induce preneoplastic lesions, and then they were orally administered with 1 µm MPs 0.5 mg/kg body weight per day for 20 weeks. The results revealed that long-term exposure to MPs did not induce the formation of glutathione

Indexed as

diethylnitrosaminehepatocarcinogenesismicrobiotamicroplasticspreneoplastic lesionsratshort chain fatty acids

Identifiers

PMID40423432
PMCPMC12115485

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.