Trial reportThe international journal of neuropsychopharmacology2025
Pharmacological modulation of directed network communication and neural hubs in action-effect integration.
Trial report in The international journal of neuropsychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Adult hippocampal neurogenesis shapes ideomotor action control in mice.Communications biology · 2026Article
- Auricular transcutaneous vagus nerve stimulation alters directed cortical communication during intentional actions.iScience · 2026Article
- A division of labor in perception-action integration via hierarchical alpha-beta to beta-gamma coupling and local catecholaminergic control.Communications biology · 2026Article
- Maturational Changes in Action-Effect Integration Processes Are Reflected by Changes in the Directed Cortical Network Communication.Human brain mapping · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundActing intentionally requires individuals to anticipate the effects of their actions. Recent work has revealed the neural oscillatory dynamics underlying the establishment of action-effect bindings, which are vital to anticipating action effects. However, the neurobiological basis of these processes is elusive.
methodsHealthy adult participants (N = 54) engaged in a double-blind, counter-balanced, placebo-controlled experiment in which they worked in an experiment able to examine how action effects are planned, anticipated, and processed under placebo and methylphenidate conditions. Electroencephalogram data were analyzed to investigate the directed communication in cortical networks underlying action effect integration.
resultsWe show that an increase in catecholaminergic system activity alters the strength of directed communication in a cortical theta frequency network constituted by the insular cortex, the anterior temporal lobe, and the inferior frontal cortex. Additionally, pharmacological modulation regulates which of the brain structures act as a hub in different phases of the action-effect binding process.
conclusionsThe findings highlight how the neural organization of processes supporting intentional action can be optimized neurobiologically through the catecholaminergic system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.