Evidence map›Paper›PMID 40423030›Full record

ArticleAntimicrobial agents and chemotherapy2025

High-throughput screening of small molecules targeting

Alejandro Armesilla-Diaz, María Pilar Arenaz, Charlotte Ashby, Delia Blanco, Emiliana D'Oria, Helena Garuti, Vanesa Gómez, Rubén González-Del-Río, María Martínez-Hoyos, Eugenia Meiler and 9 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Alejandro Armesilla-DiazGenomics Sciences, GlaxoSmithKline, Stevenage, United Kingdom.ORCID 0000-0002-3874-4115
María Pilar Arenaz *Global Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.
Charlotte AshbyGenomics Sciences, GlaxoSmithKline, Stevenage, United Kingdom.
Delia BlancoGlobal Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.
Emiliana D'OriaMMD-MD, GlaxoSmithKline, Madrid, Spain.
Helena GarutiGlobal Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.
Vanesa GómezGlobal Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.
Rubén González-Del-RíoGlobal Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.
María Martínez-HoyosGlobal Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.
Eugenia MeilerGlobal Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.ORCID 0000-0002-8538-8715
Alfonso Mendoza-LosanaGlobal Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.
Lisa MohametGenomics Sciences, GlaxoSmithKline, Stevenage, United Kingdom.
Laura Padrón-BartheGlobal Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.ORCID 0000-0002-7726-7761
Esther PérezGlobal Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.
Laura PérezGlobal Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.
Modesto J RemuiñánGlobal Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.
Beatriz Rodríguez-MiquelGlobal Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.
Delfina Segura-Carro *Global Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.
Sara Viera-MorillaGlobal Health Medicines R&D, GlaxoSmithKline, Madrid, Spain.

Funding

European Commission Innovative Medicines Initiatives 2 Joint Undertaking (grant No 853989)Ministerio de Ciencia, Innovación y UniversidadesWellcome TrustWellcome Trust 66540004Wellcome Trust 66540088
6 · The paper itself

Abstract

New treatments are still necessary to eradicate tuberculosis disease. Macrophages derived from human induced pluripotent stem cells (hiPSC-Macs) offer a physiological niche to identify potential new drugs in the context of

Indexed as

Antitubercular AgentsHigh-Throughput Screening AssaysInduced Pluripotent Stem CellsMacrophagesMycobacterium tuberculosisSmall Molecule LibrariesHumansMicrobial Sensitivity TestsTuberculosisAntitubercular AgentsSmall Molecule Librariesdrug screeninghost-pathogen interactionshuman induced pluripotent stem cellsmacrophagestuberculosis

Identifiers

PMID40423030
PMCPMC12217486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.