Evidence map›Paper›PMID 40422954›Full record

ArticleJournal of cardiovascular development and disease2025

Prevalence and Risk Factors of Acute Ischemic Stroke in Patients with Antiphospholipid Syndrome: A Retrospective Monocenter Analysis.

Paschalis Evangelidis, Nikolaos Kotsiou, Panagiotis Kalmoukos, Zacharo Ntova, Theodosia Papadopoulou, Sofia Chissan, Anastasia Sarvani, Styliani Kokoris, Elisavet Grouzi, Michael Doumas and 2 more

Abstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Paschalis EvangelidisSecond Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippocration Hospital, 54642 Thessaloniki, Greece.ORCID 0000-0003-1783-5111
Nikolaos KotsiouSecond Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippocration Hospital, 54642 Thessaloniki, Greece.ORCID 0009-0004-2919-5179
Panagiotis KalmoukosSecond Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippocration Hospital, 54642 Thessaloniki, Greece.ORCID 0009-0000-7124-2785
Zacharo NtovaSecond Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippocration Hospital, 54642 Thessaloniki, Greece.
Theodosia PapadopoulouSecond Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippocration Hospital, 54642 Thessaloniki, Greece.
Sofia ChissanSecond Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippocration Hospital, 54642 Thessaloniki, Greece.
Anastasia SarvaniSecond Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippocration Hospital, 54642 Thessaloniki, Greece.
Styliani KokorisLaboratory of Hematology and Blood Bank Unit, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0002-1635-7309
Elisavet GrouziDepartment of Transfusion Service and Clinical Hemostasis, "Saint Savvas" Oncology Hospital, 11522 Athens, Greece.
Michael DoumasSecond Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippocration Hospital, 54642 Thessaloniki, Greece.
Sofia VakalopoulouSecond Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippocration Hospital, 54642 Thessaloniki, Greece.
Eleni GavriilakiSecond Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippocration Hospital, 54642 Thessaloniki, Greece.ORCID 0000-0002-8883-8208

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Antiphospholipid syndrome (APS) is associated with thrombotic events and the laboratory identification of antiphospholipid antibodies (aPL), in which lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2 glycoprotein I antibodies are included. The aim of the current retrospective study is to examine clinical characteristics and risk factors of ischemic stroke as a clinical manifestation of APS. (2) Methods: Adult patients diagnosed with APS between 1 January 2009 and 1 June 2024 were retrospectively enrolled in this study. Sydney-revised Sapporo criteria were used for the diagnosis of APS, while ischemic stroke was diagnosed based on the acute onset of focal neurologic deficits and confirmed with radiological findings. (3) Results: We studied 115 patients with APS. Specifically, 28 (24.35%) patients, with a mean age (standard deviation) of 54 (±12.5), had ischemic stroke as a clinical manifestation of APS. In univariate analysis, stroke development was associated with the following factors: age (

Indexed as

acute ischemic strokeaGAPSSantiphospholipid syndromehypertensionthrombosis

Identifiers

PMID40422954
PMCPMC12112153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.