Evidence map›Paper›PMID 40422887›Full record

ArticleMetabolites2025

Probiotic Supplementation Improves Hematological Indices and Morphology of Red Blood Cells and Platelets in Obese Women: A Double-Blind, Controlled Pilot Study.

Nina Okuka, Nevena Dj Ivanovic, Neda Milinkovic, Snezana Polovina, Mirjana Sumarac-Dumanovic, Rajna Minic, Brizita Djordjevic, Ksenija Velickovic

Abstract read
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In one paragraph

Article in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Antihyperglycemic Activity ofMolecules (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nina OkukaDepartment of Bromatology, Faculty of Medicine, University of Banja Luka, 78000 Banja Luka, Bosnia and Herzegovina.
Nevena Dj IvanovicDepartment of Bromatology, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0001-6620-5007
Neda MilinkovicDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-2641-9817
Snezana PolovinaClinic for Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center of Serbia, 11000 Belgrade, Serbia.ORCID 0000-0003-4838-689X
Mirjana Sumarac-DumanovicSchool of Medicine, University of Belgrade, Clinic for Endocrinology, Diabetes and Diseases of Metabolism, 11000 Belgrade, Serbia.
Rajna MinicDepartment of Protein Engineering and Biochemistry, Institute of Virology, Vaccines and Sera "Torlak", 11000 Belgrade, Serbia.ORCID 0000-0003-2941-9246
Brizita DjordjevicDepartment of Bromatology, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-4582-0809
Ksenija VelickovicDepartment off Cell and Tissue Biology, Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-4373-5483

Funding

Grant Agreement with the University of Belgrade, Faculty of Pharmacy 451-03-47/2023-01/200161Ministry of Education, Science, and Technological Development, the Republic of Serbia 451-03-02141/2017-09/35
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe prevalence of obesity worldwide has rapidly increased. Numerous studies showed a beneficial effect of probiotics in obese individuals, and changes in hematological parameters are observed in obesity. Therefore, the aim of this study was to investigate the effect of a novel probiotic approach on the red blood cells (RBCs) and platelets.

methodsTwenty-five obese women participated in a randomized, placebo-controlled study and were divided into the experimental group (one capsule daily containing

resultsThe three-month supplementation of probiotics improved hemoglobin levels, chromic status, and red blood cell morphology. The mean platelet volume (MPV), a measure of platelet size, was restored to normal levels, platelet morphology was improved, and the number of activated platelets was significantly reduced (

conclusionsThe results show that the probiotic approach improves morphology and normalizes the values of disturbed hematological parameters of RBCs and platelets in obese women.

Indexed as

clinical studyhematological parametersLactiplantibacillus plantarum 299v (DSM9843)obesityoctacosanolSaccharomyces cerevisiae var. boulardii

Identifiers

PMID40422887
PMCPMC12113288

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.