Evidence map›Paper›PMID 40422846›Full record

ArticleJournal of functional biomaterials2025

Versatile Polycaprolactone-Based Drug Delivery System with Enhanced Cytocompatibility and Antibacterial Activity.

Celine Guder, Anja Hofmann, Therese Schüler, Torsten Sterzenbach, Hans-Peter Wiesmann, Katrin Lorenz, Christian Hannig, Christian Reeps, Benjamin Kruppke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Celine GuderInstitute of Materials Science, Max Bergmann Center of Biomaterials, Technische Universität Dresden, 01069 Dresden, Germany.
Anja HofmannDivision of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0002-1490-6474
Therese SchülerInstitute of Materials Science, Max Bergmann Center of Biomaterials, Technische Universität Dresden, 01069 Dresden, Germany.
Torsten SterzenbachPoliclinic of Operative Dentistry, Periodontology and Pediatric Dentristy, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Hans-Peter WiesmannInstitute of Materials Science, Max Bergmann Center of Biomaterials, Technische Universität Dresden, 01069 Dresden, Germany.
Katrin LorenzPoliclinic of Operative Dentistry, Periodontology and Pediatric Dentristy, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0002-0228-6140
Christian HannigPoliclinic of Operative Dentistry, Periodontology and Pediatric Dentristy, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Christian ReepsDivision of Vascular and Endovascular Surgery, Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Benjamin KruppkeInstitute of Materials Science, Max Bergmann Center of Biomaterials, Technische Universität Dresden, 01069 Dresden, Germany.ORCID 0000-0002-0659-0238

Funding

Deutsche Forschungsgemeinschaft 495284435 KR 5132/7-1Deutsche Forschungsgemeinschaft 495284435 LO 2960/1-1TU Dresden Research Pool 317-DFG
6 · The paper itself

Abstract

Common antibiotic therapies to treat bacterial infections are associated with systemic side effects and the development of resistance, directly connected to duration and dosage. Local drug delivery systems (DDSs) offer an alternative by localising antibiotics and thereby limiting their side effects while reducing the dosage necessary. A biodegradable polyester polycaprolactone (PCL)-based DDS was thus produced, containing various clinically relevant drugs. It was shown that the incorporation of four distinct antibiotic classes (amoxicillin, doxycycline, metronidazole and rifampicin), with very high mass fractions ranging up to 20 wt%, was feasible within the PCL matrix. This DDS showed the capacity for effective and sustained release. The release kinetics over 14 days were proven, showing a significant decrease in cytotoxicity with smooth muscle cells as well as an antibacterial effect on (1) aerobic, (2) anaerobic, (3) Gram-positive and (4) Gram-negative pathogens in vitro. The DDS demonstrated a markedly diminished cytotoxic impact owing to sustained release in comparison to pure antibiotics, while simultaneously maintaining their antibacterial efficacy. In conclusion, DDSs are a more tolerable form of antibiotics administration due to the hydrophobic PCL matrix causing a slower diffusion-controlled release, proven as a release mechanism via the Peppa-Sahlin model.

Indexed as

antibioticsantimicrobialcomposite processingcytotoxicitydegradable polyesterdrug delivery systemdrug releasesmooth muscle cells

Identifiers

PMID40422846
PMCPMC12111853

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.