Evidence map›Paper›PMID 40422831›Full record

ArticleJournal of functional biomaterials2025

Effect of Hyaluronan in Collagen Biomaterials on Human Macrophages and Fibroblasts

Nancy Avila-Martinez, Maren Pfirrmann, Madalena L N P Gomes, Roman Krymchenko, Elly M M Versteeg, Marcel Vlig, Martijn Verdoes, Toin H van Kuppevelt, Bouke K H L Boekema, Willeke F Daamen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nancy Avila-MartinezDepartment of Medical BioSciences, Research Institute for Medical Innovation, Radboud university medical center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0001-5689-9957
Maren PfirrmannDepartment of Medical BioSciences, Research Institute for Medical Innovation, Radboud university medical center, 6525 GA Nijmegen, The Netherlands.
Madalena L N P GomesDepartment of Pathology, Amsterdam University Medical Center (AUMC), Location AMC, 1081 HV Amsterdam, The Netherlands.ORCID 0009-0007-7590-3166
Roman KrymchenkoDepartment of Medical BioSciences, Research Institute for Medical Innovation, Radboud university medical center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0001-9627-8856
Elly M M VersteegDepartment of Medical BioSciences, Research Institute for Medical Innovation, Radboud university medical center, 6525 GA Nijmegen, The Netherlands.
Marcel VligAlliance of Dutch Burn Care, Burn Research Lab, 1941 AJ Beverwijk, The Netherlands.ORCID 0000-0003-3280-5877
Martijn VerdoesDepartment of Medical BioSciences, Research Institute for Medical Innovation, Radboud university medical center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0001-8753-3528
Toin H van KuppeveltDepartment of Medical BioSciences, Research Institute for Medical Innovation, Radboud university medical center, 6525 GA Nijmegen, The Netherlands.
Bouke K H L BoekemaTissue Function and Regeneration, Amsterdam Movement Sciences Research Institute, 1081 HV Amsterdam, The Netherlands.ORCID 0000-0002-9085-6982
Willeke F DaamenDepartment of Medical BioSciences, Research Institute for Medical Innovation, Radboud university medical center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-3155-3030

Funding

European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement 955722Radboud University Medical Center PhD round 2020
6 · The paper itself

Abstract

In adults, scars are formed after deep skin wound injuries like burns. However, the fetal microenvironment allows for scarless skin regeneration. One component that is abundantly present in the fetal extracellular matrix is hyaluronan (HA). To study whether biomaterials with HA improve wound healing, type I collagen scaffolds with and without HA were prepared and characterized. Their immune effect was tested using macrophages and their phenotypes were analyzed through cell surface markers and cytokine expression after 48 h. Since fibroblasts are the main cellular component in the dermis, adult, fetal and eschar-derived cells were cultured on scaffolds for 14 days and evaluated using histology, gene and protein expression analyses. Biochemical assays demonstrated that HA was successfully incorporated and evenly distributed throughout the scaffolds. Macrophages (M0) cultured on Col I+HA scaffolds exhibited a profile resembling the M2c-like phenotype (CD206

Indexed as

dermalescharfetalhyaluronic acidscaffoldsskin regeneration

Identifiers

PMID40422831
PMCPMC12112233

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.