Evidence map›Paper›PMID 40422813›Full record

ArticleThe Journal of organic chemistry2025

Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.

Lauren P Bejcek, Orugbani S Eli, Diana M Kapkayeva, Jordan Nafie, John A Beutler, Emilio Gallicchio, Dan L Sackett, Ryan P Murelli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lauren P BejcekPhD Program in Chemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States.
Orugbani S EliPhD Program in Chemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States.
Diana M KapkayevaPhD Program in Chemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States.
Jordan NafieBiotools, Inc., 17546 Bee Line Highway, Jupiter, Florida 33478, United States.
John A BeutlerMolecular Targets Program, National Cancer Institute, National Institutes of Health. 1050 Boyles Street, Frederick, Maryland 21702, United States.ORCID 0000-0002-4646-1924
Emilio GallicchioPhD Program in Chemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States.ORCID 0000-0002-2606-4913
Dan L SackettEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 1 Center Dr, Bethesda, Maryland 20892, United States.
Ryan P MurelliPhD Program in Chemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States.ORCID 0000-0002-4247-3936

Funding

Development of Natural Product Leads as Anticancer TherapeuticsZIABC011470 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BEUTLER, JOHN · 2012 to 2025
$7.8M
Development and Exploitation of New Synthetic Strategies for TropolonesSC1GM111158 · NIGMS · BROOKLYN COLLEGE · PI MURELLI, RYAN · 2015 to 2023
$3.1M
Enhancing Drug Discovery Research by Free Energy ModelingR15GM151708 · NIGMS · BROOKLYN COLLEGE · PI Emilio Gallicchio · 2023 to 2026
$1.0M
Intramural NIH HHS ZIA BC011470NIGMS NIH HHS R15 GM151708NIGMS NIH HHS SC1 GM111158
6 · The paper itself

Abstract

Colchicine is one of the oldest known microtubule-targeting agents and also represents a classic example of axial chirality and atropisomerism in medicine. This is because colchicine's axially chiral methoxytropone-trimethoxybenzene (called the AC ring) is directly responsible for tubulin binding and is thermodynamically set into the requisite

Indexed as

ColchicineTubulinTubulin ModulatorsBinding SitesHumansMolecular StructureStereoisomerismThermodynamicsColchicineTubulinTubulin Modulators

Identifiers

PMID40422813
PMCPMC12150326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.