Evidence map›Paper›PMID 40422809›Full record

ArticleMarine drugs2025

Bioactivity Assessment and Untargeted Metabolomics of the Mediterranean Sea Pen

Silvia Scarpato, Daniel Venturi, Fortunato Palma Esposito, Maria Cristina Mangano, Gianluca Sarà, Francesco Margiotta, Ester Pagano, Maria Miraglia, Enrico Sangiovanni, Mercedes Garcia-Gil and 7 more

Abstract read
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Silvia ScarpatoDepartment of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via A.F. Acton, Molosiglio, 80133 Naples, Italy.
Daniel VenturiDepartment of Neuroscience, Psychology, Drug Research and Child Health-Neurofarba-Section of Pharmacology and Toxicology, University of Florence, 50139 Florence, Italy.ORCID 0009-0006-3933-0236
Fortunato Palma EspositoDepartment of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via A.F. Acton, Molosiglio, 80133 Naples, Italy.ORCID 0000-0002-3768-4712
Maria Cristina ManganoDepartment of Integrated Marine Ecology, Stazione Zoologica Anton Dohrn, Sicily Marine Centre, Lungomare Cristoforo Colombo (Complesso Roosevelt), 90142 Palermo, Italy.ORCID 0000-0001-6980-9834
Gianluca SaràNBFC, National Biodiversity Future Center, Piazza Marina 61, 90133 Palermo, Italy.ORCID 0000-0002-7658-5274
Francesco MargiottaDepartment of Neuroscience, Psychology, Drug Research and Child Health-Neurofarba-Section of Pharmacology and Toxicology, University of Florence, 50139 Florence, Italy.ORCID 0000-0002-4172-2478
Ester PaganoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, 80138 Naples, Italy.
Maria MiragliaDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, 80138 Naples, Italy.
Enrico SangiovanniDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0003-2811-8628
Mercedes Garcia-GilDepartment of Biology, University of Pisa, 56127 Pisa, Italy.ORCID 0000-0002-1344-2786
Lorenzo Di Cesare MannelliDepartment of Neuroscience, Psychology, Drug Research and Child Health-Neurofarba-Section of Pharmacology and Toxicology, University of Florence, 50139 Florence, Italy.ORCID 0000-0001-8374-4432
Carla GhelardiniDepartment of Neuroscience, Psychology, Drug Research and Child Health-Neurofarba-Section of Pharmacology and Toxicology, University of Florence, 50139 Florence, Italy.
Mario Dell'AgliDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0001-5378-402X
Angelo A IzzoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, 80138 Naples, Italy.
Paola NieriDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0001-5809-2938
Donatella de PascaleDepartment of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via A.F. Acton, Molosiglio, 80133 Naples, Italy.
Gerardo Della SalaDepartment of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Via A.F. Acton, Molosiglio, 80133 Naples, Italy.ORCID 0000-0001-8957-3259

Funding

INTERREG Italy-Malta projects "HARMONY" Operational Program call n. 01/2017 Grant C1-3.1-31PO FEAMP Sicilia 2014/2020 Codice SIPA 07/RBC/20-CUP G79C19000090009"SenHAR" Operational Program call n. 02/2019 C.2-3.1-115
6 · The paper itself

Abstract

Octocorals have proven to be a prolific source of bioactive natural products, exhibiting a wide spectrum of pharmacological activities. Among octocorals, Pennatulaceans, commonly known as sea pens, are among the most dominant soft coral species living in benthic communities. Nonetheless, reports on bioactivity and chemical investigations of this genus are scarce. This prompted us to shed light on the pharmacological potential of the extracts of the sea pen

Indexed as

AnthozoaAnti-Inflammatory AgentsBiological ProductsAnimalsCell Line, TumorCell SurvivalHumansMediterranean SeaMetabolomeMetabolomicsAnti-Inflammatory AgentsBiological Productsanti-inflammatory effectanti-melanoma activitycisplatinum-induced cytotoxicity protectionglycerophospholipidsmass spectrometrymolecular networkingoctocoralsPennatula phosphoreaphosphosphingolipidsprostaglandins

Identifiers

PMID40422809
PMCPMC12113132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.