Evidence map›Paper›PMID 40422784›Full record

ArticleMarine drugs2025

Isolation and Characterization of L-Asparaginase-Producing Bacteria from the Arabian-Persian Gulf Region: First Report on

Ghofran M Al-Harbi, Essam Kotb, Abeer A Almiman, Mahmoud M Berekaa, Salwa Alhamad, Nada F Alahmady, Meneerah A Aljafary, Nadiyah M Alqazlan, Reem I Alyami, Joud M Alqarni and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ghofran M Al-HarbiDepartment of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam 31441, Saudi Arabia.
Essam KotbDepartment of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam 31441, Saudi Arabia.ORCID 0000-0002-2209-8761
Abeer A AlmimanDepartment of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam 31441, Saudi Arabia.
Mahmoud M BerekaaDepartment of Environmental Health, College of Public Health, Imam Abdulrahman Bin Faisal University (IAU), Dammam 31441, Saudi Arabia.ORCID 0000-0002-5427-6761
Salwa AlhamadDepartment of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam 31441, Saudi Arabia.ORCID 0000-0002-3030-6241
Nada F AlahmadyDepartment of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam 31441, Saudi Arabia.ORCID 0000-0002-6203-2070
Meneerah A AljafaryDepartment of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam 31441, Saudi Arabia.
Nadiyah M AlqazlanDepartment of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam 31441, Saudi Arabia.ORCID 0009-0001-0221-5940
Reem I AlyamiDepartment of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam 31441, Saudi Arabia.ORCID 0000-0001-9806-6769
Joud M AlqarniDepartment of Biology, College of Science, Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam 31441, Saudi Arabia.ORCID 0009-0006-3412-1005
Ebtesam Abdullah Al-SuhaimiBasic and Applied Scientific Research Center (BASRC), Imam Abdulrahman Bin Faisal University (IAU), P.O. Box 1982, Dammam 31441, Saudi Arabia.ORCID 0000-0003-1614-0211

Funding

Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia IF-2020-028-BASRC
6 · The paper itself

Abstract

L-asparaginase (L-ASNase) functions as a chemotherapeutic enzyme with antitumor properties. It facilitates the degradation of L-asparagine (L-ASN), a vital amino acid required for the proliferation of tumor cells. In this study, we have isolated 177 L-ASNase-producing strains from the aquatic environment of the Arabian-Persian Gulf. The most potent isolate, ASP-J1-4, was an endophyte recovered from the seablite

Indexed as

Antineoplastic AgentsAsparaginaseBacillusAsparagineCell Line, TumorHCT116 CellsHumansHydrogen-Ion ConcentrationIndian OceanAntineoplastic AgentsAsparaginaseAsparagineantitumorArabian–Persian GulfBacillus xiamenensisL-asparaginasemarine bacteriamarine drugs

Identifiers

PMID40422784
PMCPMC12113540

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.