Evidence map›Paper›PMID 40422762›Full record

ArticleMembranes2025

Membrane ATPases and Mitochondrial Proteins in Fetal Cerebellum After Exposure to L-Glutamate During Gestation.

Adrián Tejero, David Agustín León-Navarro, Mairena Martín

Abstract read
In one paragraph

Article in Membranes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adrián TejeroDepartment of Inorganic and Organic Chemistry and Biochemistry, Faculty of Chemical Sciences and Technologies, Institute of Biomedicine, Investigación Sanitaria de Castilla-La Mancha, University of Castilla-La Mancha, Avenida Camilo José Cela 10, 13071 Ciudad Real, Spain.ORCID 0000-0002-8226-8793
David Agustín León-NavarroDepartment of Inorganic and Organic Chemistry and Biochemistry, Faculty of Chemical Sciences and Technologies, Institute of Biomedicine, Investigación Sanitaria de Castilla-La Mancha, University of Castilla-La Mancha, Avenida Camilo José Cela 10, 13071 Ciudad Real, Spain.ORCID 0000-0002-5539-9237
Mairena MartínDepartment of Inorganic and Organic Chemistry and Biochemistry, Faculty of Chemical Sciences and Technologies, Institute of Biomedicine, Investigación Sanitaria de Castilla-La Mancha, University of Castilla-La Mancha, Avenida Camilo José Cela 10, 13071 Ciudad Real, Spain.ORCID 0000-0002-6843-3449

Funding

Juta de Comunidades de Castilla-La Mancha SBPLY/23/180225/000156Ministerio de Ciencia, Innovación y Universidades PID2022-140602NB-100predoctoral Manuel Oya 2022 fellowship from Fundación Cerveza y Salud CR-2023-103Universidad de Castilla-La Mancha 2022-GRIN-34201
6 · The paper itself

Abstract

L-Glutamate (L-Glu) and its salt derivatives are widely used in the food industry as flavor enhancers. Although the consumption of these compounds is generally considered safe, some studies suggest that chronically consuming L-Glu may be associated with various disorders. In this study, Wistar pregnant rats were treated daily with 1 g/L of L-Glu in their drinking water throughout the gestational period. OPA-1, DRP-1, and mitofusin 2-key proteins involved in mitochondrial fusion and fission-were analyzed by Western blot. The results showed that L-Glu exposure significantly decreased DRP-1 levels, while OPA-1 and mitofusin 2 levels were unaffected. This was accompanied by a notable decrease in mitochondrial complexes III and V. The activities of Mg

Indexed as

L-glutamateMg2+-ATPasemitochondria

Identifiers

PMID40422762
PMCPMC12113180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.