ArticlemBio2025
Pseudouridine synthases are proviral factors for Sindbis virus in insect and mammalian cells.
Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Alphaviruses are positive-sense, single-stranded RNA (+ssRNA) viruses transmitted by arthropod vectors to vertebrate hosts. Pseudouridine is the most prevalent RNA modification in the prototype alphavirus, Sindbis virus (SINV) genome, but the location, function, and the cellular machinery that deposits pseudouridine are not known. Here, we demonstrate that the host pseudouridine synthase, Nop60B, plays a proviral role in SINV replication in IMPORTANCE: Alphaviruses pose a threat to over half of the global population, and currently, there are no approved antivirals targeting alphaviruses. We identified a conserved pseudouridine synthase that is proviral for Sindbis virus (SINV) infection in insects and humans. Using Psi-seq, we identified putative pseudouridine residues in SINV RNA. Mutagenesis of putative psi sites led to a slight reduction in replication and suggests that pseudouridine residues in SINV RNA are functionally important in replication.
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