Evidence map›Paper›PMID 40422587›Full record

ArticleDiseases (Basel, Switzerland)2025

Increased Degenerative Biomarkers in Females with Patellofemoral Pain: A Cross-Sectional Analysis with 6-Month Progression.

Lori A Bolgla, Tiana V Curry-McCoy, Maya Giddens, Madelyn Overton, Bryaunna Barrera, Jasmine Crockett, Monte Hunter

Abstract read
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In one paragraph

Article in Diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lori A BolglaDepartment of Physical Therapy, College of Allied Health Sciences, Augusta University, Augusta, GA 30912, USA.
Tiana V Curry-McCoyDepartment of Undergradaute Health Professions-Clinical Laboratory Science Program, College of Allied Health Sciences, Augusta University, Augusta, GA 30912, USA.
Maya GiddensDepartment of Undergradaute Health Professions-Clinical Laboratory Science Program, College of Allied Health Sciences, Augusta University, Augusta, GA 30912, USA.
Madelyn OvertonDepartment of Undergradaute Health Professions-Clinical Laboratory Science Program, College of Allied Health Sciences, Augusta University, Augusta, GA 30912, USA.
Bryaunna BarreraDepartment of Undergradaute Health Professions-Clinical Laboratory Science Program, College of Allied Health Sciences, Augusta University, Augusta, GA 30912, USA.
Jasmine CrockettDepartment of Undergradaute Health Professions-Clinical Laboratory Science Program, College of Allied Health Sciences, Augusta University, Augusta, GA 30912, USA.
Monte HunterDepartment of Orthopaedic Surgery, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

Funding

Patellofemoral Pain and Knee Osteoarthritis: When are degenerative changes apparent?R15AG063105 · NIA · AUGUSTA UNIVERSITY · PI BOLGLA, LORI · 2019 to 2019
$451k
National Institutes of Aging R15AG063105NIA NIH HHS R15 AG063105
6 · The paper itself

Abstract

BACKGROUND/

objectivesPatellofemoral pain (PFP) is considered a risk factor for knee osteoarthritis (OA) onset. The purpose of this study was to compare degenerative biomarkers in females with and without PFP and to determine changes in these levels, along with pain and function, over 6 months.

methodsAll subjects received a knee x-ray to ensure that none had degenerative changes. Urine and serum were collected and analyzed for C-telopeptide fragments of type II collagen (CTX-II) and C-propeptide II (CP-II); these were then expressed as a cartilage degradation: cartilage synthesis ratio (CTX-II:CP-II). Subjects with PFP rated pain using a 10 cm visual analog scale, and function using the Knee injury and Osteoarthritis Outcome Scores-Patellofemoral (KOOS-PF) questionnaire. Subjects with PFP were tested at baseline and at 6 months.

resultsFemales with PFP had higher levels of CTX-II:CP-II than controls (

conclusionsFemales with PFP but no evident structural changes had more elevated biomarkers than controls. This finding suggests that this cohort may have excessive cartilage turnover which may contribute to knee OA.

Indexed as

anterior knee paincartilagecollagendegenerationprognosisprospective

Identifiers

PMID40422587
PMCPMC12110012

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.