Evidence map›Paper›PMID 40422555›Full record

Observational studyActa odontologica Scandinavica2025

Self-reported oral health outcomes after switching to a novel nicotine pouch technology: a pilot study.

Giusy Rita Maria La Rosa, Karl Fagerström, Sebastiano Antonio Pacino, Jan Kowalski, Renata Górska, Stefan Gospodaru, Gheorghe Bordeniuc, Valeriu Fala, Amaliya Amaliya, Iain Chapple and 1 more

Abstract readObservational Study
In one paragraph

Observational study in Acta odontologica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giusy Rita Maria La RosaDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy. giusy.larosa@unict.it.
Karl FagerströmFagerström Consulting, Stockholm, Sweden.
Sebastiano Antonio PacinoAddendo srl, Dental Clinic, Catania, Italy.
Jan KowalskiDepartment of Periodontology, Medical University of Warsaw, Warsaw, Poland.
Renata GórskaDepartment of Periodontology, Medical University of Warsaw, Warsaw, Poland.
Stefan GospodaruFaladental, Chișinău, Republic of Moldova.
Gheorghe BordeniucFaladental, Chișinău, Republic of Moldova; 'Nicolae Testemiţanu' State University of Medicine and Pharmacy, Chişinău, Republic of Moldova.
Valeriu FalaFaladental, Chișinău, Republic of Moldova; 'Nicolae Testemiţanu' State University of Medicine and Pharmacy, Chişinău, Republic of Moldova.
Amaliya AmaliyaDepartment of Periodontology, Faculty of Dentistry, Universitas Padjadjaran, West Java, Indonesia.
Iain ChapplePeriodontal Research Group, Institute of Clinical Sciences, College of Medical & Dental Sciences, The University of Birmingham, Birmingham, UK; Birmingham Community Healthcare NHS Foundation Trust, Birmingham, UK.
Riccardo PolosaDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy; Faculty of Medicine and Surgery, 'Kore' University of Enna, Kore, Italy; Center of Excellence for the Acceleration of Harm Reduction (CoEHAR), University of Catania, Catania, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNicotine pouch use has been linked to oral health concerns, including oral lesions and gingival irritation. This pilot study examines self-reported oral health outcomes following the use of a novel nicotine pouch (Stingfree Strong Blue Mint), with an impermeable barrier on the interior side designed to reduce mucosal irritation. MATERIALS AND

methodsA total of 23 Swedish dentists who were current snus or nicotine pouch users participated in a 5-week observational study. Baseline and follow-up assessments included self-reported oral health status and photographic documentation of mucosal conditions, reviewed by an independent blinded dental expert. Primary outcomes included changes in self-reported snus lesions, gingival recession, gingival irritation, and gingivitis.  Results: The prevalence of self-reported snus lesions decreased from 95.7% (n = 22) to 69.6% (n = 16). Median Axell-scale lesion severity declined from 2 (interquartile range [IQR]: 1-3) to 1 (IQR: 0-2) (z = 3.756, p = 0.0002). Moderate-to-severe lesions (Axell score ≥ 3) dropped from 39.1% (n = 9) to 0% (n = 0). Self-reported gingivitis cases (n = 3) were eliminated, and gingival irritation decreased by 90.0%.

conclusionsPreliminary findings suggest that the use of the Stingfree Strong Blue Mint nicotine pouch may reduce mucosal irritation. While promising, these findings warrant validation through large randomised controlled trials to establish long-term effectiveness and safety.

Indexed as

NicotineOral HealthTobacco, SmokelessAdultFemaleGingivitisHumansMaleMiddle AgedPilot ProjectsSelf ReportNicotine

Identifiers

PMID40422555
PMCPMC12138386

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.