Evidence map›Paper›PMID 40422537›Full record

ReviewCurrent oncology (Toronto, Ont.)2025

Mechanistic Insights and Future Directions for Enfortumab Vedotin in Urothelial Carcinoma: Highlights from the 10th Annual Leo & Anne Albert Institute for Bladder Cancer Care and Research Symposium.

Catherine C Fahey, Sean Clark-Garvey, Sima Porten, Ashish M Kamat, Thomas W Flaig, John A Taylor, William Y Kim, Matthew I Milowsky

Abstract readReview
In one paragraph

Review in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Catherine C FaheyLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Sean Clark-GarveyLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Sima PortenDepartment of Urology, University of California, San Francisco, CA 94143, USA.
Ashish M KamatDepartment of Urology, MD Anderson Cancer Center, Houston, TX 77030, USA.
Thomas W FlaigDepartment of Medicine, University of Colorado, Aurora, CO 80045, USA.
John A TaylorDepartment of Urology, University of Kansas, Kansas City, KS 66160, USA.
William Y KimLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0001-7922-2156
Matthew I MilowskyLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0002-8965-8129

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enfortumab vedotin (EV) in combination with pembrolizumab (P) has led to a new paradigm for the treatment of metastatic urothelial carcinoma (mUC). Since the presentation of the results of the EV-302 trial at the European Society of Medical Oncology 2023 annual meeting, the entire treatment landscape for mUC has been upended. At the 2024 Albert Symposium, we reviewed ongoing research investigating predictive biomarkers for EV response and resistance as well as clinical trials exploring the potential role for EV in different clinical disease states including non-muscle invasive and muscle-invasive disease.

Indexed as

Antibodies, MonoclonalAntibodies, Monoclonal, HumanizedCarcinoma, Transitional CellUrinary Bladder NeoplasmsHumansAntibodies, MonoclonalAntibodies, Monoclonal, Humanizedenfortumab vedotinpembrolizumabantibody drug conjugatebiomarkersenfortumab vedotinimmunotherapypembrolizumaburothelial carcinoma

Identifiers

PMID40422537
PMCPMC12110689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.