Evidence map›Paper›PMID 40422374›Full record

ArticleGels (Basel, Switzerland)2025

Development of an Asymmetric Alginate Hydrogel Loaded with S-Nitrosoglutathione and Its Application in Chronic Wound Healing.

Jiafeng Tan, Minna Wen, Yifan Zhang, Shuyun Zhang, Min Fang, Junxiao Xiang, Xinshuo Liu, Jinhuan Tian, Lu Lu, Binghong Luo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Nitric Oxide-ReleasingPharmaceutics · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiafeng TanEngineering Research Center of Artificial Organs and Materials, College of Chemistry and Materials, Jinan University, Guangzhou 510632, China.
Minna WenEngineering Research Center of Artificial Organs and Materials, College of Chemistry and Materials, Jinan University, Guangzhou 510632, China.
Yifan ZhangEngineering Research Center of Artificial Organs and Materials, College of Chemistry and Materials, Jinan University, Guangzhou 510632, China.
Shuyun ZhangCollege of Public Security and Traffic Management, Guangdong Police College, Guangzhou 510440, China.
Min FangEngineering Research Center of Artificial Organs and Materials, College of Chemistry and Materials, Jinan University, Guangzhou 510632, China.
Junxiao XiangEngineering Research Center of Artificial Organs and Materials, College of Chemistry and Materials, Jinan University, Guangzhou 510632, China.
Xinshuo LiuEngineering Research Center of Artificial Organs and Materials, College of Chemistry and Materials, Jinan University, Guangzhou 510632, China.
Jinhuan TianEngineering Research Center of Artificial Organs and Materials, College of Chemistry and Materials, Jinan University, Guangzhou 510632, China.
Lu LuEngineering Research Center of Artificial Organs and Materials, College of Chemistry and Materials, Jinan University, Guangzhou 510632, China.
Binghong LuoEngineering Research Center of Artificial Organs and Materials, College of Chemistry and Materials, Jinan University, Guangzhou 510632, China.
Changren ZhouEngineering Research Center of Artificial Organs and Materials, College of Chemistry and Materials, Jinan University, Guangzhou 510632, China.
Lihua LiEngineering Research Center of Artificial Organs and Materials, College of Chemistry and Materials, Jinan University, Guangzhou 510632, China.

Funding

China National Postdoctoral Program for Innovative Talents BX20240153Guangdong Basic and Applied Basic Research Foundation 2024A1515220075Guangdong Provincial Medical Science and Technology Research Fund B2024147National Natural Science Foundation of China NSFC-32301134
6 · The paper itself

Abstract

Nitric oxide (NO) is an endogenous signaling molecule that plays a critical role in wound healing. However, the gaseous nature, short half-life, and low stability of NO present challenges for its clinical application. To address these issues, this study introduces an innovative S-nitrosoglutathione (GSNO)-loaded asymmetric alginate (SA) hydrogel (GSNO-SA) as a novel solution for treating infected chronic wounds. The hydrogel is designed with a layer-by-layer melting-permeation crosslinking approach, forming a dense upper layer and a sparse lower layer structure, effectively promoting exudate management while delaying NO release. The results demonstrate that the GSNO-SA hydrogel extends NO release for up to 48 h, exhibits rapid exudate absorption (72.3 ± 1.5% equilibrium swelling after 5 min), significant antibacterial activity (over 90% antibacterial rate against

Indexed as

asymmetrical hydrogelchronic woundsinfectious woundsS-nitrosoglutathionesodium alginate

Identifiers

PMID40422374
PMCPMC12111571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.