Evidence map›Paper›PMID 40422336›Full record

ReviewGels (Basel, Switzerland)2025

Current Utilization of Gel-Based Scaffolds and Templates in Foot and Ankle Surgery-A Review.

Julia E Ralph, Bradley J Lauck, Charles B Colson, Santita Ebangwese, Conor N O'Neill, Albert T Anastasio, Samuel B Adams

Abstract readReview
In one paragraph

Review in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julia E RalphDuke University School of Medicine, Durham, NC 27710, USA.ORCID 0009-0001-7703-9400
Bradley J LauckUniversity of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Charles B ColsonGeorgetown University School of Medicine, Washington, DC 20007, USA.ORCID 0009-0006-0891-6365
Santita EbangweseDuke University School of Medicine, Durham, NC 27710, USA.
Conor N O'NeillDepartment of Orthopedic Surgery, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0003-4456-9445
Albert T AnastasioDepartment of Orthopedic Surgery, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0001-5817-3826
Samuel B AdamsDepartment of Orthopedic Surgery, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0003-1020-1167

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As tissue engineering and regenerative medicine (TERM) continues to revolutionize medicine and surgery, there is also growing interest in applying these advancements to foot and ankle surgery. The purpose of this article is to provide a comprehensive review of the types of gel scaffolds and templates, their applications in foot and ankle surgery, the challenges with current utilization, and the future directions of TERM in foot and ankle surgery. With multiple compelling scaffold prospects across the numerous natural, synthetic, and hybrid polymers currently utilized in TERM, promising results have been described in the treatment of osteoarthritis (OA) and osteochondral lesions (OCLs). However, concerns with material biocompatibility, structural integrity, feasibility during surgery, and degradation still exist and limit the extent of utilization. As researchers continue to develop enhanced polymers and formulations that address current issues, there are many opportunities to increase applications across foot and ankle surgery.

Indexed as

arthritisfoot and ankle surgerygelsosteochondral lesionsscaffoldstemplates

Identifiers

PMID40422336
PMCPMC12111285

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.