Evidence map›Paper›PMID 40422326›Full record

ReviewGels (Basel, Switzerland)2025

Advancements in the Field of Protein-Based Hydrogels: Main Types, Characteristics, and Their Applications.

Gábor Katona, Bence Sipos, Ildikó Csóka

Abstract readReview
In one paragraph

Review in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gábor KatonaInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös Street 6., H-6720 Szeged, Hungary.ORCID 0000-0003-1564-4813
Bence SiposInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös Street 6., H-6720 Szeged, Hungary.ORCID 0000-0002-0131-4728
Ildikó CsókaInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös Street 6., H-6720 Szeged, Hungary.ORCID 0000-0003-0807-2781

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regenerative medicine is a challenging field in current research and development, whilst translating the findings of novel tissue regenerative agents into clinical application. Protein-based hydrogels are derived from various sources, with animal-derived products being primarily utilized to deliver cells and promote cell genesis and proliferation, thereby aiding in numerous indications, including bone tissue regeneration, cartilage regeneration, spinal cord injury, and wound healing. As biocompatible and biodegradable systems, they are tolerated by the human body, allowing them to exert their beneficial effects in many indications. In this review article, multiple types of animal-derived proteins (e.g., collagen, gelatin, serum albumin, fibrin) were described, and a selection of the recent literature was collected to support the claims behind these innovative systems. During the literature review, special indications were found when applying these hydrogels, including the therapeutic option to treat post-myocardial infarct sites, glaucoma, and others. Maintaining their structure and mechanical integrity is still challenging. It is usually solved by adding (semi)synthetic polymers or small molecules to strengthen or loosen the mechanical stress in the hydrogel's structure. All in all, this review points out the potential application of value-added delivery systems in regenerative medicine.

Indexed as

collagenelastinfibringelatinhydrogelproteinregenerative medicineserum albuminsilk fibroin

Identifiers

PMID40422326
PMCPMC12111179

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.