Evidence map›Paper›PMID 40422246›Full record

ArticleCells2025

The Effects of Neuronal

Nikhil S Rao, Marson Putra, Christina Meyer, Sirisha Parameswaran, Thimmasettappa Thippeswamy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nikhil S RaoDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University of Science and Technology, Ames, IA 50011, USA.
Marson PutraDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University of Science and Technology, Ames, IA 50011, USA.
Christina MeyerDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University of Science and Technology, Ames, IA 50011, USA.ORCID 0000-0002-8714-1089
Sirisha ParameswaranDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University of Science and Technology, Ames, IA 50011, USA.
Thimmasettappa ThippeswamyDepartment of Biomedical Sciences, College of Veterinary Medicine, Iowa State University of Science and Technology, Ames, IA 50011, USA.ORCID 0000-0002-9326-1896

Funding

Mechanisms of Neurodegeneration in a Nerve Agent ModelR01NS133584 · NINDS · IOWA STATE UNIVERSITY · PI Thimmasettappa Thippeswamy · 2024 to 2026
$1.4M
Fyn Mediated Neuroinflammatory Signaling in Epileptogenesis and EpilepsyR21NS112779 · NINDS · IOWA STATE UNIVERSITY · PI THIPPESWAMY, THIMMASETTAPPA · 2020 to 2020
$407k
NINDS NIH HHS R01 NS133584NINDS NIH HHS R21 NS112779
6 · The paper itself

Abstract

Previous studies have demonstrated neuronal and microglial Fyn, a Src family kinase (SFK), and how its interactions with tau contribute to epileptogenesis. Saracatinib, a Fyn/SFK inhibitor, modifies disease progression in rat kainate (KA) epilepsy models. In this study, we investigated neuronal-specific

Indexed as

Epilepsy, Temporal LobeHippocampusNeuronsProto-Oncogene Proteins c-fynAnimalsDisease Models, AnimalDisks Large Homolog 4 ProteinGene Knockdown TechniquesKainic AcidMalePhosphorylationRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSignal Transductiontau ProteinsDisks Large Homolog 4 ProteinFyn protein, ratKainic AcidProto-Oncogene Proteins c-fynReceptors, N-Methyl-D-Aspartatetau Proteinsepilepsyfyn knockdownneurodegenerationneuroinflammationSrc family kinase

Identifiers

PMID40422246
PMCPMC12110385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.