Evidence map›Paper›PMID 40422240›Full record

ArticleCells2025

Recognizing Epithelial Cells in Prostatic Glands Using Deep Learning.

Liton Devnath, Puneet Arora, Anita Carraro, Jagoda Korbelik, Mira Keyes, Gang Wang, Martial Guillaud, Calum MacAulay

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liton DevnathIntegrative Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0001-7606-3719
Puneet AroraIntegrative Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.
Anita CarraroIntegrative Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.
Jagoda KorbelikIntegrative Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.
Mira KeyesBC Cancer Agency, Vancouver, BC V5Z 4E9, Canada.
Gang WangPathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
Martial GuillaudIntegrative Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.
Calum MacAulayIntegrative Oncology, BC Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0003-4440-2792

Funding

CIHR MOP-142198
6 · The paper itself

Abstract

Artificial intelligence (AI) is becoming an integral part of pathological assessment and diagnostic procedures in modern pathology. As most prostate cancers (PCa) arise from glandular epithelial tissue, an AI-based methodology has been developed to recognize glandular epithelial nuclei in prostate biopsy tissue. An integrated machine-learning network, named GlandNet, was developed to correctly recognize the epithelial cells within prostate glands using cell-centric patches selected from the core biopsy specimens. Feulgen-Thionin (a DNA stoichiometric label) was used to stain biopsy sections (4-7 µm in thickness) from 82 active surveillance patients diagnosed with PCa. Images of these sections were human-annotated, and the resultant dataset consisted of 1,264,772 segmented, cell-centric nuclei patches, of which 449,879 were centered on epithelial gland nuclei from 110 needle biopsies (training set:

Indexed as

Deep LearningEpithelial CellsProstateProstatic NeoplasmsHumansMaledeep learningepithelial cellmachine learningprostate cancerprostatic glandssemi-supervised methodstoichiometric DNA stainstromal cell

Identifiers

PMID40422240
PMCPMC12109630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.