Evidence map›Paper›PMID 40422238›Full record

ArticleCells2025

The Competitive Loss of Cerebellar Granule and Purkinje Cells Driven by X-Linked Mosaicism in a Female Mouse Model of CASK-Related Disorders.

Takuma Mori, Mengyun Zhou, Ken Kunugitani, Taichi Akatsuka, Yukina Yoshida, Emi Kouyama-Suzuki, Shin Kobayashi, Yoshinori Shirai, Katsuhiko Tabuchi

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Takuma MoriDepartment of Molecular and Cellular Physiology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0002-4195-2804
Mengyun ZhouDepartment of Molecular and Cellular Physiology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0001-8095-7133
Ken KunugitaniDepartment of Molecular and Cellular Physiology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Taichi AkatsukaDepartment of Molecular and Cellular Physiology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Yukina YoshidaDepartment of Molecular and Cellular Physiology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Emi Kouyama-SuzukiDepartment of Molecular and Cellular Physiology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Shin KobayashiCellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Tokyo 135-0064, Japan.ORCID 0000-0001-6639-3810
Yoshinori ShiraiDepartment of Molecular and Cellular Physiology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0002-3263-4986
Katsuhiko TabuchiDepartment of Molecular and Cellular Physiology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.ORCID 0000-0002-1673-4637

Funding

Japan Epilepsy Research Foundation TMJapan Science and Technology Agency JPMJSP2144Japan Society for the Promotion of Science 21K07293Japan Society for the Promotion of Science 23H02575Japan Society for the Promotion of Science 23H04227Mochida Memorial Foundation for Medical and Pharmaceutical Research TMNaito Foundation TMSENSHIN Medical Research Foundation KTTakeda Science Foundation TM
6 · The paper itself

Abstract

CASK-related disorders are a form of female-restricted intellectual disabilities associated with cerebellar and pontine hypoplasia. The

Indexed as

CerebellumGuanylate KinasesMosaicismPurkinje CellsAnimalsDisease Models, AnimalFemaleMaleMiceMice, KnockoutX Chromosome InactivationCASK kinasesGuanylate KinasesCASKcell autonomouscell competitioncerebellumMICPCHX-chromosome inactivation

Identifiers

PMID40422238
PMCPMC12109812

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.