Evidence map›Paper›PMID 40422215›Full record

ArticleCells2025

FAM20B Gain-of-Function Blocks the Synthesis of Glycosaminoglycan Chains of Proteoglycans and Inhibits Proliferation and Migration of Glioblastoma Cells.

Lydia Barré, Irfan Shaukat, Mohamed Ouzzine

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lydia BarréUMR7365 CNRS-Université de Lorraine, Biopôle, Faculté de Médecine, CS 50184, 54505 Vandoeuvre-lès-Nancy Cedex, France.ORCID 0000-0002-4593-6190
Irfan ShaukatUMR7365 CNRS-Université de Lorraine, Biopôle, Faculté de Médecine, CS 50184, 54505 Vandoeuvre-lès-Nancy Cedex, France.
Mohamed OuzzineUMR7365 CNRS-Université de Lorraine, Biopôle, Faculté de Médecine, CS 50184, 54505 Vandoeuvre-lès-Nancy Cedex, France.

Funding

Région Lorraine Région Lorraine
6 · The paper itself

Abstract

Heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans (PGs) are essential regulators of many biological processes including cell differentiation, signalization, and proliferation. PGs interact mainly via their glycosaminoglycan (GAG) chains, with a large number of ligands including growth factors, enzymes, and extracellular matrix components, thereby modulating their biological activities. HSPGs and CSPGs share a common tetrasaccharide linker region, which undergoes modifications, particularly the phosphorylation of the xylose residue by the kinase FAM20B. Here, we demonstrated that

Indexed as

GlioblastomaGlycosaminoglycansProteoglycansCell Line, TumorCell MovementCell ProliferationHumansGlycosaminoglycansProteoglycansFAM20Bglioblastomaglycosaminoglycan synthesisproteoglycans

Identifiers

PMID40422215
PMCPMC12110425

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.