Evidence map›Paper›PMID 40422182›Full record

ArticleCells2025

Impact of Drp1 Loss on Organelle Interaction, Metabolism, and Inflammation in Mouse Liver.

Lixiang Wang, Seiji Nomura, Nao Hasuzawa, Sadaki Yokota, Ayako Nagayama, Kenji Ashida, Junjiro Rikitake, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lixiang WangDepartment of Medical Biochemistry, Kurume University School of Medicine, Kurume 830-0011, Japan.
Seiji NomuraDepartment of Medical Biochemistry, Kurume University School of Medicine, Kurume 830-0011, Japan.ORCID 0009-0001-7706-1034
Nao HasuzawaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan.
Sadaki YokotaDivision of Functional Morphology, Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo 859-3243, Japan.
Ayako NagayamaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan.
Kenji AshidaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan.ORCID 0000-0001-8753-6016
Junjiro RikitakeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan.
Yoshinori MoriyamaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan.
Masatoshi NomuraDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan.ORCID 0000-0002-0725-3161
Ken YamamotoDepartment of Medical Biochemistry, Kurume University School of Medicine, Kurume 830-0011, Japan.ORCID 0000-0002-1531-9685

Funding

Japan Society for the Promotion of Science 22K08663
6 · The paper itself

Abstract

Dynamin-related protein 1 (Drp1) is a crucial player in mitochondrial fission and liver function. The interactions between mitochondria, endoplasmic reticulum (ER), and lipid droplets (LDs) are fundamental for lipid metabolism. This study utilized liver-specific Drp1 knockout (

Indexed as

DynaminsInflammationLiverOrganellesAnimalsEndoplasmic ReticulumHepatocytesLipid DropletsLipid MetabolismMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaMitochondrial DynamicsDnm1l protein, mouseDynaminsdynamin-related protein 1lipid metabolismliver inflammationorganelle interaction

Identifiers

PMID40422182
PMCPMC12109831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.