ArticleBiosensors2025
MIP-Modified Porous Silicon Optical Sensor for Interleukin-6 Label-Free Quantification.
Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Optical and Electrochemical Biosensors Using Electrochemically Etched Porous Silicon.Biosensors · 2026Review
- Simultaneous Electrochemical Detection of NGF and proNGF Under Native Conditions Using Molecularly Imprinted Polymers: Toward Point-of-Care Diagnosis of Alzheimer's Disease.Advanced healthcare materials · 2026Article
- LPFG Biosensor for IL-6 Detection in Murine Serum Samples Associated with Ischemic Disease.Sensors (Basel, Switzerland) · 2026Article
- Advances in Porous Silicon Materials for Sensing, Energy Storage, and Microelectronics.Nanomaterials (Basel, Switzerland) · 2026Review
- A Molecularly Imprinted Polymer-Based Porous Silicon Optical Sensor for Quercetin Detection in Wines.ACS applied materials & interfaces · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we present an innovative optical biosensor designed to detect Interleukin-6 (IL-6), a pivotal cytokine implicated in many pathological conditions. Our sensing platform is made of a porous silicon (PSi) nanostructured substrate modified with a thin (~5 nm) molecularly imprinted polymer (MIP), ensuring both high specificity and sensitivity toward IL-6 molecules. The fabrication process involves electrochemical etching of silicon chips to create the porous structure, followed by the electrodeposition of the MIP, which is tailored to selectively bind the IL-6 target. Extensive testing over a broad IL-6 concentration range demonstrates a clear, proportional optical response, yielding a limit of detection (LOD) of 13 nM. Moreover, the biosensor robustness was verified by evaluating its performance in bovine serum, a complex biological matrix. Despite the presence of various interfering components, the sensor maintained its selectivity and displayed minimal matrix effects, underlining its practical applicability in real-world diagnostic scenarios.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.