Evidence map›Paper›PMID 40422030›Full record

ArticleBiosensors2025

A Dual-Signal Electrochemiluminescence Sensor for Kanamycin Detection Based on a Self-Enhanced Zr MOF and Single Co-Reactant Competition Mechanism.

Yawen Zhu, Xuemei Wang, Zhiyong Yan, Feifei Zhang, Jianfei Xia, Lili Lv, Zonghua Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Ultrasensitive Detection ofBiosensors · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yawen ZhuInstrumental Analysis Center of Qingdao University, College of Chemistry and Chemical Engineering, Qingdao Application Technology Innovation Center of Photoelectric Biosensing for Clinical Diagnosis and Treatment, Qingdao University, Qingdao 266071, China.
Xuemei WangInstrumental Analysis Center of Qingdao University, College of Chemistry and Chemical Engineering, Qingdao Application Technology Innovation Center of Photoelectric Biosensing for Clinical Diagnosis and Treatment, Qingdao University, Qingdao 266071, China.
Zhiyong YanInstitute of Analysis and Testing, Beijing Academy of Science and Technology, Beijing Center for Physical and Chemical Analysis, Beijing 100089, China.
Feifei ZhangInstrumental Analysis Center of Qingdao University, College of Chemistry and Chemical Engineering, Qingdao Application Technology Innovation Center of Photoelectric Biosensing for Clinical Diagnosis and Treatment, Qingdao University, Qingdao 266071, China.
Jianfei XiaInstrumental Analysis Center of Qingdao University, College of Chemistry and Chemical Engineering, Qingdao Application Technology Innovation Center of Photoelectric Biosensing for Clinical Diagnosis and Treatment, Qingdao University, Qingdao 266071, China.
Lili LvInstrumental Analysis Center of Qingdao University, College of Chemistry and Chemical Engineering, Qingdao Application Technology Innovation Center of Photoelectric Biosensing for Clinical Diagnosis and Treatment, Qingdao University, Qingdao 266071, China.
Zonghua WangInstrumental Analysis Center of Qingdao University, College of Chemistry and Chemical Engineering, Qingdao Application Technology Innovation Center of Photoelectric Biosensing for Clinical Diagnosis and Treatment, Qingdao University, Qingdao 266071, China.ORCID 0000-0002-9120-4089

Funding

National Natural Science Foundation of China No.22304013, No. 52203119the Natural Science Foundation of Shandong Province ZR2020MB063, ZR2021MB069, ZR2020MB060the Taishan Scholar Program of Shandong Province ts201511027
6 · The paper itself

Abstract

The dual-signal output self-calibration mode reduces the false positive and negative signals of electrochemiluminescence (ECL) aptamer sensors. A competitive dual-signal ECL platform was designed for the ultrasensitive detection of kanamycin (KAN) using a zirconium metal-organic framework (Zr MOF) and Luminol as ECL emitters. To enhance the ECL efficiency, a co-reactant (polyethyleneimine, PEI) was covalently bound to the Zr MOF to achieve self-enhanced ECL. Based on the selective interaction between KAN and its aptamer, the Luminol/KAN/Zr MOF-PEI "sandwich" structure was immobilized on the electrode surface. The competition for PEI between emitters increased the Luminol ECL signal and decreased the Zr MOF's ECL signal. The ratio in ECL signals between the two competitive emitters enabled the quantitative analysis of KAN, achieving a detection limit as low as 7.86 × 10

Indexed as

Biosensing TechniquesElectrochemical TechniquesKanamycinLuminescent MeasurementsMetal-Organic FrameworksAptamers, NucleotideElectrodesLimit of DetectionLuminolZirconiumAptamers, NucleotideKanamycinLuminolMetal-Organic FrameworksZirconiumco-reactant competitiondual-signalkanamycinluminolself-enhanced electrochemiluminescencezirconium metal organic framework

Identifiers

PMID40422030
PMCPMC12109509

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.