ArticleMedicina oral, patologia oral y cirugia bucal2025
Risk factors associated with prognosis in patients with osteoradionecrosis of the jaws: A single institutional experience over 15 years.
Article in Medicina oral, patologia oral y cirugia bucal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Identifying risk factors for osteoradionecrosis of the jaws: a systematic review and meta-analysis.Clinical oral investigations · 2026Pooled it
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoradionecrosis of the jaws (ORNJ) is a pernicious complication of radiation therapy that significantly affects the quality of life of patients with head and neck cancer. The present study aimed to investigate the risk factors for the clinical prognosis of ORNJ in the same scenario. MATERIAL AND
methodsA cross-sectional study was designed and implemented in a tertiary teaching hospital from January 2005 to December 2020. A total of 106 patients were divided into normal wound healing group (n = 79) and delayed wound healing group (n = 27) according to two different prognosis. The risk factors associated with the prognosis in patients with ORNJ were comparatively analyzed via performing one-way and multifactorial logistic analyses.
resultsThe majority of the study cohort (n = 59, 55.7%) was found to be characterized with Glanzmann and Gratz grade 2 and followed up for a median of 38.6 months. Diabetes mellitus (P = .045), Charlson comorbidity index (P = .042), American Society of Anesthesiologists score (P < .001), primary tumour site (P = .012), T stage (P = .008), ORNJ grade at initial diagnosis (P < .001), pan-immune-inflammatory value and systemic immune-inflammatory index at initial radiotherapy (P = .01 and P < .001 respectively) were detected as risk factors associated with poor prognosis in patients with ORNJ.
conclusionsWe conclude that there are abundant risk factors for poor prognosis in these patients, and it is important to be evaluated before irradiation so that suitable post-radiated treatments can be given.
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