SynthesisMedicina oral, patologia oral y cirugia bucal2025
Does the use of proton pump inhibitors lead to an increased risk of dental implant failure? A systematic review and meta-analysis.
Synthesis in Medicina oral, patologia oral y cirugia bucal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Dental implant failure and retrieval techniques; a scoping review.Frontiers in oral health · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProton-pump inhibitors (PPI) are one of the commonly used medications for a variety of gastrointestinal disorders. Given the large population using PPI and the increased use of dental implants in recent times, it is pertinent to examine if PPI impacts implant outcomes. This systematic review examined the risk of implant failure amongst PPI users vs non-users. MATERIAL AND
methodsPubMed, Embase, Scopus, and Web of Science literature databases were scouted for cohort or case-control studies comparing implant survival between PPI users vs non-users. Last date of the literature search was 30th October 2024.
resultsWe identified eight studies for inclusion. Both crude and adjusted data were pooled separately. Meta-analysis of crude data demonstrated that there was a statistically significant risk of implant failure in PPI users as compared to non-users (OR: 2.71 95% CI: 1.72, 4.29 I2 = 63%). These results failed to change on sensitivity analysis. Pooled analysis of adjusted data showed that PPI use may not independently predict implant failure (OR: 1.44 95% CI: 0.92, 2.24 I2 = 73%). Exclusion of one outlier study showed a significantly increased risk of implant failure with PPI use (OR: 1.71 95% CI: 1.17, 2.50 I2 = 42%).
conclusionsThere may be a tendency for higher implant failure in patients using PPI. The lack of stability of the results on sensitivity analysis and non-significant associations noted with adjusted data preclude strong conclusions. There is a need for further high-quality studies to strengthen the available evidence.
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Registered trials
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