SynthesisMedicina oral, patologia oral y cirugia bucal2025
The effect of dexmedetomidine on perioperative events of orthognathic surgery: a systematic review of randomized controlled trials.
Synthesis in Medicina oral, patologia oral y cirugia bucal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Dexmedetomidine for opioid-sparing postoperative analgesia: a systematic review and meta-analysis.BMC anesthesiology · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOrthognathic surgery is a complex invasive procedure associated with common postoperative symptoms and patient-related events. Dexmedetomidine is an emerging sedative and hypotensive agent that has demonstrated safety and efficacy in perioperative care of other craniofacial procedures. MATERIAL AND
methodsAn electronic search was performed in seven primary databases (Cochrane Library, Embase, LILACS, MedLine via PubMed, SciELO, Scopus, and Web of Science) and one additional (EASY) to partially capture the gray literature. The PICO strategy was used to identify randomized clinical trials evaluating the effect of dexmedetomidine on perioperative events in patients undergoing orthognathic surgery compared to placebo or control groups, without restrictions on publication language and year. Two independent reviewers performed data extraction and assessed the risk of bias using the RoB 2.0 tool.
resultsThe search identified 401 records, of which six studies met the eligibility criteria, including 282 patients from five countries, and published between 2008 and 2023. Outcomes were categorized into six groups based on available data: 1) Airway and Respiratory Events, 2) Emetic Events, 3) Hemodynamic Events, 4) Length of Hospital Stay, 5) Neurological Events, and 6) Pain Burden. Dexmedetomidine reduced coughing and maintained hemodynamic stability but did not prevent emergence agitation. It was associated with lower intraoperative fentanyl use and reduced rescue analgesia requirements. Postoperatively, dexmedetomidine effectively controlled pain, nausea, and vomiting, with significantly lower pain scores and reduced analgesic demand. Among the six studies, only one was classified as high risk of bias due to issues in the randomization process, while the others were categorized as low risk of bias. A meta-analysis was planned but could not be conducted due to high heterogeneity among studies.
conclusionsDexmedetomidine appears to be a safe and effective option for reducing postoperative symptoms such as pain, nausea, vomiting, and cough in orthognathic surgery, while maintaining hemodynamic stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.